Abstract
Histiocytic necrotizing lymphadenitis, or Kikuchi’s disease (KD), is a self-limited
clinicopathologic entity recognized increasingly worldwide. A 27-year-old man with
cervical lymphadenopathy and fever who was diagnosed with KD developed mild headache
with no nuchal rigidity. The cerebrospinal fluid (CSF) was sterile and contained 78
white blood cells/mm3 with lymphocytes predominating, accompanied by smaller numbers of monocytes and granulocytes.
This abnormality normalized spontaneously over 5 weeks. Eleven similar cases have
been reported, all but one from Japan. The development of meningitis in KD was observed
in four (9.8%) of 41 KD patients we have treated, suggesting that the meningitis was
related to KD and not merely coincidental.
Keywords
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Article info
Publication history
Accepted:
January 18,
1999
Received in revised form:
December 31,
1998
Received:
August 31,
1998
Identification
Copyright
© 1999 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
