Abstract
The effects of hindlimb temperature on sciatic nerve and skeletal muscle laser Doppler
vascular conductance (LDVC) were assessed in anesthetized control and streptozotocin
(STZ)-diabetic rats. With core temperature at 37°C and exposed hindlimb temperature
at 32°C, nerve LDVC was significantly lower in rats after 8 weeks of STZ diabetes
than in age-matched control rats. Subsequent warming of the exposed hindlimb of control
rats from 32°C to 37°C significantly decreased nerve LDVC by 41% and increased muscle
LDVC by 48%. Because nerve LDVC was unchanged by hindlimb warming in STZ-diabetic
rats, there was no significant difference between control and diabetic nerve LDVC
at 37°C. In a second study, after 6 weeks of STZ diabetes, changes from control nerve
LDVC were shown to depend on temperature rather than the duration of surgical exposure.
These findings emphasize that information about hindlimb temperature is a prerequisite
for interpreting the effects of experimental diabetes on hindlimb nerve blood flow.
Keywords
Abbreviations:
LDVC, laser Doppler vascular conductance (), MNCV, motor nerve conduction velocity (), NBF, nerve blood flow (), NLDF, nerve laser Doppler flow (), STZ, streptozotocin. ()To read this article in full you will need to make a payment
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References
- Endoneurial blood flow and oxygen tension in the sciatic nerve of rats with experimental diabetic neuropathy.Brain. 1984; 107: 935-950
- Sural nerve oxygen tension in diabetes.Br Med J. 1986; 293: 1053-1054
- Regional blood flow in resting and stimulated sciatic nerve of diabetic rats.Exp Neurol. 1988; 99: 607-614
- Effects of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats: comparison with aldose reductase inhibitor ONO 2235.Diabetes. 1989; 38: 832-838
- Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits.Am J Physiol. 1991; 261: 1-8
- Effect of niceritrol on streptozocin-induced diabetic neuropathy in rats.Diabetes. 1992; 41: 587-591
- Effects of nimodipine on sciatic nerve blood flow and vasa nervorum responsiveness in the diabetic rat.Eur J Pharmacol. 1993; 250: 43-49
- Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat.Br J Pharmacol. 1994; 111: 887-893
- Angiotensin II receptor blockade improves nerve function, modulates nerve blood flow and stimulates endoneurial angiogenesis in streptozotocin-diabetic rats.Diabetologia. 1993; 36: 1230-1237
- Essential fatty acid treatment prevents nerve ischaemia and associated conduction anomalies in rats with experimental diabetes mellitus.Diabetologia. 1993; 36: 397-401
- Aldose reductase inhibition, Doppler flux and conduction in diabetic rat nerve.Eur J Pharmacol. 1994; 251: 27-33
- Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: dose-response considerations and independence from a myo-inositol mechanism.Diabetologia. 1994; 37: 651-663
- Effects of evening primrose oil treatment on sciatic nerve blood flow and endoneurial oxygen tension in streptozotocin-diabetic rats.Acta Diabetol. 1994; 31: 220-225
- Nerve ischemia in diabetic rats: time-course of development, effect of insulin treatment plus comparison of streptozotocin and BB models.Diabetologia. 1994; 37: 43-48
- Effects of antioxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats: comparison with essential fatty acids.Diabetologia. 1995; 38: 129-134
- Effects of endothelin receptor antagonism with bosentan on peripheral nerve function in experimental diabetes.Br J Pharmacol. 1995; 115: 373-379
- Hyperglycemic pseudohypoxia and diabetic complications.Diabetes. 1993; 42: 801-813
- Diabetes impairs sciatic nerve hyperemia induced by surgical trauma: implications for diabetic neuropathy.Am J Physiol. 1997; 273: 174-184
- Normal blood flow but lower oxygen tension in diabetes of young rats: microenvironment and the influence of sympathectomy.Can J Physiol Pharmacol. 1992; 70: 651-659
- The influence of indomethacin and guanethidine on experimental streptozotocin diabetic neuropathy.Can J Neurol Sci. 1992; 19: 433-441
- The influence of Sulindac on experimental streptozotocin-induced diabetic neuropathy.Can J Neurol Sci. 1994; 21: 194-202
- Diabetes increases sciatic nerve susceptibility to endothelin-induced ischemia.Diabetes. 1996; 45: 627-632
- Effects of body and hindlimb temperature on laser Doppler blood flow and vascular conductance in rat sciatic nerve and skeletal muscle.J Neurol Sci. 1997; 148: 7-13
- Absence of autoregulation in peripheral nerve blood flow.J Neurol Sci. 1977; 33: 347-352
- Effects of changes of blood pressure, respiratory acidosis and hypoxia on blood flow in the sciatic nerve of the rat.J Physiol. 1984; 347: 513-523
- Blood flow in rat sciatic nerve during hypotension.Exp Neurol. 1985; 90: 139-148
- Antidromic vasodilatation in the rat hindpaw measured by laser Doppler flowmetry: pharmacological modulation.J Auton Nerv Syst. 1987; 19: 105-111
- Efficacy of limb cooling on the salvage of peripheral nerve from ischemic fiber degeneration.Muscle Nerve. 1996; 19: 203-209
- Selective impairment of hindquarters vasodilator responses to bradykinin in conscious Wistar rats with streptozotocin-induced diabetes mellitus.Br J Pharmacol. 1991; 103: 1357-1362
- The effects of endothelin-1 and NG-nitro-L-arginine methyl ester on regional haemodynamics in conscious rats with streptozotocin-induced diabetes mellitus.Br J Pharmacol. 1991; 103: 1321-1326
- General Anesthetics.in: Gilman A.G. Rall T.W. Nies A.S. Taylor P. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 8th ed. Pergamon Press, New York1990: 285-310 (Chapter 14)
- Peripheral nerve structure and function in experimental diabetes.J Neurol Sci. 1974; 23: 1-15
- Fast orthograde axonal transport in sciatic motoneurones and nerve temperature in streptozotocin-diabetic rats.Diabetologia. 1985; 28: 847-851
- Short-term oscillations of aortic core temperature and thermogenic organ blood flow in the rat.Exp Physiol. 1993; 78: 243-253
- Elevated regional sciatic nerve blood flow in hypothermic anesthetized rats.Exp Neurol. 1987; 97: 383-390
- Regional blood flow in sciatic nerve, biceps femoris muscle, and truncal skin in response to haemorrhagic hypotension.J Trauma. 1987; 27: 1025-1030
- Nerve and muscle blood flow during hindlimb ischemia and reperfusion in rats.J Neurosurg. 1994; 80: 1078-1084
- Limb ischemia and reperfusion: relationship of functional recovery to nerve and muscle blood flow.J Trauma. 1994; 36: 555-560
- Effect of norepinephrine on regional sciatic nerve blood flow.Microvasc Res. 1995; 49: 190-200
- Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system.Pharmacol Rev. 1992; 44: 103-150
- Adrenergic control of nerve blood flow.Exp Neurol. 1990; 109: 300-307
- Regional sciatic nerve and muscle blood flow in conscious and anesthetized rats.Am J Physiol. 1986; 251: 1211-1216
- Effect of surgical trauma on regional blood flow in rat sciatic nerve.Exp Neurol. 1994; 125: 296-301
- The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications.Diabetes Metab Rev. 1994; 10: 189-224
- Neuroprotective effects of carvedilol in diabetic rats: prevention of defective peripheral nerve perfusion and conduction velocity.Naunyn Schmiedebergs Arch Pharmacol. 1995; 351: 630-635
- Comparison of the effects of evening primrose oil and triglycerides containing gamma-linoleic acid on nerve conduction and blood flow in diabetic rats.J Pharmacol Exp Ther. 1995; 273: 49-55
- Effects of beraprost sodium and insulin on the electroretinogram, nerve conduction and nerve blood flow in rats with streptozotocin-induced diabetes.Diabetes. 1996; 45: 361-366
- Effect of propionyl-L-carnitine on motor nerve conduction, autonomic cardiac function and nerve blood flow in rats with streptozotocin-induced diabetes: comparison with an aldose reductase inhibitor.J Pharmacol Exp Ther. 1996; 276: 49-55
- Prevention of haemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors.Diabetes. 1989; 38: 1258-1270
- Neuropathology and blood flow of nerve, spinal roots and dorsal root ganglia in longstanding diabetic rats.Acta Neuropathol (Berl). 1997; 93: 118-128
- Metabolic effect of PGE1 analogue 01206.alpha CD on nerve Na(+)-K(+)-ATPase activity of rats with streptozotocin-induced diabetes is mediated via cAMP: possible role of cAMP in diabetic neuropathy.Prostaglandins. 1994; 47: 367-378
- Anoxic block and recovery of axoplasmic transport and electrical excitability of nerve.J Neurobiol. 1978; 9: 229-245
Article info
Publication history
Accepted:
January 11,
1999
Received in revised form:
November 16,
1998
Received:
July 8,
1998
Identification
Copyright
© 1999 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
