Abstract
To investigate the characteristics of regional cerebral metabolism in a subgroup of
patients with Parkinson’s disease and autonomic failure, we studied seven patients
with Parkinson’s disease with autonomic failure (PA group), 11 patients with Parkinson’s
disease without apparent autonomic failure (PD group), and nine normal controls using
fluoro-deoxyglucose positron emission tomography (FDG-PET). To determine differences
in metabolic distribution among these groups, regional relative glucose metabolic
rates (RGMR), which were normalized with cerebellar values, were calculated and age-adjusted
covariance analyses were done. When compared with that of controls, RGMR in the cerebral
cortex of the PA group was markedly reduced in the occipital cortex (P<0.001), inferior parietal cortex (P<0.005) and superior parietal cortex (P<0.005), but without a decrease in the sensory motor and medial temporal cortices,
putamen and thalamus. In contrast, the PD group did not show significant focal hypometabolic
distribution. Our findings raise the possibility that Parkinson’s disease with autonomic
failure may overlap with the features of dementia with Lewy bodies.
Keywords
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Article info
Publication history
Accepted:
December 14,
1998
Received in revised form:
November 2,
1998
Received:
August 12,
1998
Identification
Copyright
© 1999 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
