Abstract
To determine if circadian clock function is affected by thiamine deficiency, the rhythm
of locomotor (wheel-running) activity was measured in a murine model of dietary thiamine
deficiency. About 1 month before the expected onset of overt neurological illness,
locomotor rhythmicity in deficient animals exhibited a shortened free-running period
without a change in amplitude. This effect was fully reversible by thiamine administration.
Disordered circadian timekeeping may contribute to altered physiological responses
in Wernicke’s encephalopathy.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Organization of circadian rhythmicity and suprachiasmatic nuclei in malnourished rats.Am J Physiol. 1997; 273: R1321-R1331
- Thyroid gland influences the period of hamster circadian oscillations.Experientia. 1982; 38: 870-871
- Ventromedial hypothalamic lesions prevent the fasting-induced changes in day–night pattern of locomotor activity.Behav Brain Res. 1996; 77: 155-163
- Some regional pathologic and metabolic consequences in mouse brain of pyrithiamine-induced thiamine deficiency.J Neuropath Exp Neurol. 1970; 29: 57-69
- An effect of castration and testosterone replacement on a circadian pacemaker in mice (Mus musculus).Proc Natl Acad Sci USA. 1975; 72: 3744-3747
- Chronobiotics – drugs that shift rhythms.Pharmacol Ther. 1996; 69: 15-36
- Lesions of chronic thiamine deficiency in mice.J Natl Cancer Inst. 1947; 8: 139-155
- Circadian rhythm photic phase shifts are not altered by histamine receptor antagonists.Brain Res Bull. 1996; 41: 227-229
- The role of glutamate in the photic regulation of the suprachiasmatic nucleus.Prog Neurobiol. 1996; 50: 109-132
- Activity feedback to the mammalian circadian pacemaker: influence on observed measures of rhythm period length.J Biol Rhythms. 1991; 6: 185-199
- Temperature dependence of the hamster circadian pacemaker.Am J Physiol. 1983; 244: R607-R610
- Sequence of metabolic, clinical, and histological events in experimental thiamine deficiency.Ann Neurol. 1983; 13: 365-375
- Thiamine deficiency-induced disruptions in the diurnal rhythm and regulation of body temperature in the rat.Metab Brain Dis. 1998; 13: 225-239
- Protective effects of the glutamate antagonist MK-801 on pyrithiamine-induced lesions and amino acids changes in rat brain.J Neurosci. 1990; 10: 1664-1674
- Differential serotonergic innervation of the suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm modulation.J Neurosci. 1996; 16: 2097-2111
- Alterations in serotonin parameters in brain of thiamine-deficient rats are evident prior to the appearance of neurological symptoms.J Neurochem. 1996; 67: 1113-1123
- Regional changes in brain histamine levels following dietary-induced thiamine deficiency in rats.Japan J Pharmacol. 1988; 47: 323-326
- Understanding circadian clocks: from c-fos to fly balls.Ann Neurol. 1997; 41: 289-297
- Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains.J Neurosci. 1990; 10: 3685-3694
- Age-related changes in the hamster’s circadian system partially reversed by treatment with sulbutiamine, a vit b-1 related compound.Biol Rhythm Res. 1994; : 25
- The Wernicke-Korsakoff syndrome. F.A. Davis, Philadelphia1971
- Pyrithiamine-induced acute thiamine-deficient encephalopathy in the mouse.Exp Molec Pathol. 1978; 28: 381-394
- Impaired melatonin secretion in patients with Wernicke-Korsakoff syndrome.J Int Med. 1995; 237: 571-575
Article info
Publication history
Accepted:
November 17,
1998
Received in revised form:
November 5,
1998
Received:
July 2,
1998
Identification
Copyright
© 1999 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
