Research Article| Volume 163, ISSUE 1, P6-10, February 01, 1999

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Altered circadian rhythmicity is an early sign of murine dietary thiamine deficiency


      To determine if circadian clock function is affected by thiamine deficiency, the rhythm of locomotor (wheel-running) activity was measured in a murine model of dietary thiamine deficiency. About 1 month before the expected onset of overt neurological illness, locomotor rhythmicity in deficient animals exhibited a shortened free-running period without a change in amplitude. This effect was fully reversible by thiamine administration. Disordered circadian timekeeping may contribute to altered physiological responses in Wernicke’s encephalopathy.


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