Research Article| Volume 163, ISSUE 1, P53-57, February 01, 1999

Download started.


Are Campylobacter curvus and Campylobacter upsaliensis antecedent infectious agents in Guillain–Barré and Fisher’s syndromes?


      Campylobacter curvus and Campylobacter upsaliensis were isolated from stools of patients with Guillain–Barré (GBS) or Fisher’s (FS) syndromes. Whether these microorganisms are pathogens of antecedent diarrhea in GBS and FS is not clear, therefore, we made a serological examination. There were no differences in antibody titer to these organisms among the patients with GBS, FS, and the controls. Some patients had elevated antibodies to the bacteria, but most also had serological evidence of C. jejuni infection. Moreover, the patients from whom C. curvus had been isolated did not have antibodies to the bacterium, indicative that they were healthy carriers of C. curvus or that the isolates were the product of contamination. We conclude that neither C. curvus nor C. upsaliensis is the major agent of antecedent diarrhea in GBS and FS.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Asbury A.K.
        • Cornblath D.R.
        Assessment of current diagnostic criteria for Guillain–Barré syndrome.
        Ann Neurol. 1990; 27: S21-24
        • Goossens H.
        • Vlaes L.
        • De Boeck M.
        • et al.
        Is “Campylobacter upsaliensis”: an unrecognised [sic] cause of human diarrhoea?.
        Lancet. 1990; 335: 584-586
        • Ho T.W.
        • Hsieh S.-T.
        • Nachamkin I.
        • et al.
        Motor nerve terminal degeneration provides a potential mechanism for rapid recovery in acute motor axonal neuropathy after Campylobacter infection.
        Neurology. 1997; 48: 717-724
        • Hughes R.A.C.
        • Rees J.H.
        Clinical and epidemiologic features of Guillain–Barré syndrome.
        J Infect Dis. 1997; 176: S92-98
        • Koga M.
        • Yuki N.
        • Takahashi M.
        • Saito K.
        • Hirata K.
        Close association of IgA anti-ganglioside antibodies with antecedent Campylobacter jejuni infection in Guillain–Barré and Fisher’s syndromes.
        J Neuroimmunol. 1998; 81: 138-143
        • Lastovica A.J.
        • Roux E.L.
        • Penner J.L.
        Campylobacter upsaliensis isolated from blood cultures of pediatric patients.
        J Clin Microbiol. 1989; 27: 657-659
        • Lastovica A.J.
        • Goddard E.A.
        • Argent A.C.
        Guillain–Barré syndrome in South Africa associated with Campylobacter jejuni O: 41 strains.
        J Infect Dis. 1997; 176: S139-143
        • Patton C.M.
        • Shaffer N.
        • Edmonds P.
        • et al.
        Human disease associated with Campylobacter upsaliensis (catalase-negative or weakly positive Campylobacter species) in the United States.
        J Clin Microbiol. 1989; 27: 66-73
        • Rees J.H.
        • Soudain S.E.
        • Gregson N.A.
        • Hughes R.A.C.
        Campylobacter jejuni infection and Guillain–Barré syndrome.
        N Engl J Med. 1995; 333: 1374-1379
      1. Ropper AH, Wijdicks EFM, Truax BT. Guillain–Barré Syndrome, F.A. Davis, Philadelphia, 1991, pp. 18–21.

        • Tanner A.C.R.
        • Listgarten M.A.
        • Ebersole J.L.
        Wollinella curva sp. nov.: Vibrio succinogenes of human origin.
        Int J Syst Bacteriol. 1984; 34: 275-282
        • Yuki N.
        • Taki T.
        • Inagaki F.
        • et al.
        A bacterium lipopolysaccharide that elicits Guillain–Barré syndrome has a GM1 ganglioside-like structure.
        J Exp Med. 1993; 178: 1771-1775
        • Yuki N.
        Molecular mimicry between gangliosides and lipopolysaccharides of Campylobacter jejuni isolated from patients with Guillain–Barré syndrome and Miller Fisher syndrome.
        J Infect Dis. 1997; 176: S150-153