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Research Article| Volume 163, ISSUE 1, P70-73, February 01, 1999

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Akinetic mutism and mixed transcortical aphasia following left thalamo–mesencephalic infarction

      Abstract

      A 54-year-old man developed somnolent akinetic mutism and acute mixed transcortical aphasia following a left thalamo–mesencephalic infarction. He also exhibited behavioural changes, namely apathy, slowness, lack of spontaneity, disinhibition, perseveration, gait apraxia and incontinence consistent with frontal lobe dysfunction. Presumably the akinetic mutism and language dysfunction were due to the thalamic stroke. All the manifestations could be related to interruption of the frontal-subcortical circuitry.

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      References

        • Amyes E.W
        • Neilson J.M
        Bilateral anterior cingulate gyrus lesions.
        Bull Los Angeles Neuro Sci. 1953; 18: 48-57
        • Alexander M.I.P
        • LoVerme Jr., S.R
        Aphasia after left hemispheric intracerebral haemorrhage.
        Neurology. 1980; 30: 193-202
        • Barris R.W
        • Schuman H.R
        Bilateral anterior cingulate gyrus lesions.
        Neurology. 1953; 3: 44-52
        • Bell D.S
        Speech functions of the thalamus inferred from the effects of thalamotomy.
        Brain. 1968; 91: 619-638
        • Berthier M.L
        • Starkstein S.E
        • Leiguardia R
        • Ruiz A
        • Mayberg H.S
        • Wagner H
        • Price T.R
        • Robinson R.G
        Transcortical aphasia; importance of non-speech dominant hemisphere in language repetition.
        Brain. 1990; 1: 631-641
        • Bogousslavsky J
        • Ferrazzi N.I.M
        • Regli F
        • Assal G
        • Tanabe H
        • Delaloye-Bischof A
        Manic delirium frontal-like syndrome with paramedian infarction of the right thalamus.
        J Neurol Neurosurg Psychiatry. 1988; 51: 116-119
        • Bogousslavsky J
        Frontal stroke syndromes.
        Eur Neurol. 1994; 34: 306-315
        • Brown J.W
        Language cognition and the thalamus.
        Confin Neurologica. 1979; 36: 35-60
        • Cairns H
        • Oldfield H.C
        • Pennybaker J.B
        • Whineridge D
        Akinetic mutism with an epidermoid cyst of the third ventricle.
        Brain. 1941; 34: 273-290
        • Castaigne P
        • Lhermitte F
        • Buge A
        • Escourolle R
        • Hauw J.J
        • Lyon-Caen O
        Paramedian thalamic and midbrain infarcts: clinical and neuropathological study.
        Ann Neurol. 1980; 10: 127-148
        • Cravioto H
        • Silberman J
        • Fergin I.A
        A clinical and pathologic study of akinetic mutism.
        Neurology. 1960; 17: 74-80
        • Cummings J.L
        Frontal-subcortical circuits and human behaviour.
        Arch Neurol. 1993; 50: 873-880
        • Geschwind N
        • Quadfasel F.A
        • Segarra J.M
        Isolation of the speech area.
        Neuropsychologia. 1968; 6: 327-340
        • Glosser G
        • Kaplan E
        • LoVerme S
        Longitudinal neuropsychological report of aphasia following left subcortical haemorrhage.
        Brain Lang. 1982; 15: 95-116
        • Hawker K
        • Lang A.F
        Hypoxic-ischaemic damage of the basal ganglia.
        Mov Disord. 1990; 5: 219-224
        • Kawahara N
        • Sato K
        • Murak M
        • Tanaka K
        • Kaneko M
        • Uemura K
        CT classification of small thalamic haemorrhages and their clinical implications.
        Neurology. 1986; 30: 65-172
        • Kemper T.L
        • Romanul F.C.A
        State resembling akinetic mutism in basilar artery occlusion.
        Neurology. 1967; 17: 74-80
        • Laplane D
        • Degos J.D
        • Baulac M
        • Gray F
        Bilateral infarction of the anterior cingulate gyriand of the fornices.
        J Neurol Sci. 1981; 51: 289-300
        • McFarling D
        • Rothi L.J
        • Heilman K.M
        Transcortical aphasia from ischaemic infarcts of the thalamus. Report of two cases.
        J Neurol Neurosurg Psychiatry. 1982; 45: 107-112
        • Mega M.S
        • Cohenour R.C
        Akinetic mutism: disconnection of frontal subcortical circuits.
        Neuropsychiatry Neuropsychol Behav Neurol. 1997; 10: 254-259
        • Meissner I
        • Sapir S
        • Kokmen E
        • Stein S.D
        The paramedian diencephalic syndrome: a dynamic phenomenon.
        Stroke. 1987; 18: 380-385
        • Mohr J.P
        • Watters W.C
        • Duncan G.W
        Thalamic haemorrhage and aphasia.
        Brain Lang. 1975; 2: 3-17
        • Nagratnam N
        • Goughassian D.F
        • Mugridge V
        Syndrome of downward gaze palsy, amnesia and hypersomnolence.
        Postgrad Med J. 1989; 65: 840-842
        • Nagaratnam N
        • Gilhotra J.S
        Acute mixed transcortical aphasia following an infarction in the left putamen.
        Aphasiology. 1998; 12: 489-493
        • Nagaratnam N
        • Barnes R
        Language dysfunction in white matter lesions without significant hemiparesis.
        J Neurol Rehab. 1996; 10: 253-256
        • Nemeth G
        • Hyedus K
        • Molnar L
        Akinetic mutism associated with bicingular lesions: a clinicopathological and functional anatomic correlates.
        Eur Arch Psychiatry Neuro Sci. 1988; 237: 218-222
        • Park-Matsumoto Y.C
        • Ogawa K
        • Tazawa T
        • Ishiai S
        • Tei H
        • Yuasa T
        Mutism developing after bilateral thalamo–capsular lesions by neuro-Bechet disease.
        Acta Neurol Scand. 1995; 91: 297-301
        • Plum F
        • Posner Y.B
        Diagnosis of stupor and coma. F.A.Davis, Philadelphia1972: 23-24
        • Rapscak S.Z
        • Krupp L.B
        • Rubens A.B
        • Reim M.J
        Mixed transcortical aphasia without isolation of the speech area.
        Stroke. 1990; 21: 953-956
        • Ross E.D
        Left medial parietal lobe and receptive language functions; mixed transcortical aphasia after left anterior cerebral infarction.
        Neurology. 1980; 30: 144-150
        • Sandson T.A
        • Daffner K.R
        • Carvalho P.A
        • Meslman M.M
        Frontal lobe dysfunction following infarction of the left-sided medial thalamus.
        Arch Neurol. 1991; 8: 1300-1303
        • Segarra J.M
        Cerebral vascular disease and behaviour. I. The syndrome of the mesencephalic artery.
        Arch Neurol. 1970; 22: 408-418
        • Strub R.L
        Frontal lobe syndrome in a patient with bilateral globus pallidus lesion.
        Arch Neurol. 1989; 46: 1024-1027
        • Weisberg L.A
        Thalamic haemorrhage: clinical-CT correlation.
        Neurology. 1986; 36: 1382-1386