Abstract
Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of
various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients
who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous
for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of
this trait may contribute to susceptibility to NMS.
Keywords
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Article info
Publication history
Accepted:
July 13,
1998
Received in revised form:
July 9,
1998
Received:
January 12,
1998
Identification
Copyright
© 1998 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
