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Rapid Communication| Volume 160, ISSUE 1, P102-104, September 18, 1998

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Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome

      Abstract

      Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of this trait may contribute to susceptibility to NMS.

      Keywords

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      References

        • Pope H.G
        • Keck P.E
        • McElroy S.L
        Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital.
        Am. J. Psychiatry. 1983; 143: 1227-1233
        • Deuschl G
        • Oepen G
        • Hermle L
        Neuroleptic malignant syndrome: Observations on altered consciousness.
        Pharmacopsychiatry. 1987; 20: 168-170
        • Otani K
        • Horiuchi M
        • Kondo T
        • Kaneko S
        • Fukushima Y
        Is the predisposition to neuroleptic malignant syndrome genetically transmitted?.
        Br. J. Psychiatry. 1991; 158: 850-853
        • Iwahashi K
        CYP2D6 genotype and possible susceptibility to the neuroleptic malignant syndrome.
        Biol. Psychiatry. 1994; 36: 781-782
        • Ram A
        • Cao Q
        • Keck P.E
        • Pope H.G
        • Otani K
        • Addonizio G
        • MaElroy S.L
        • Kaneko S
        • Redlichova M
        • Gershon E.S
        • Gejman P.V
        Structural change in dopamine D2 receptor gene in a patient with neuroleptic malignant syndrome.
        Am. J. Med. Genet. 1995; 60: 228-230
        • Wang S.-L
        • Huang J.-D
        • Lai M.-D
        • Liu B.-H
        • Lai M.-L
        Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6.
        Clin. Pharmacol. Ther. 1993; 53: 410-418
        • Kawanishi C
        • Hanihara T
        • Maruyama Y
        • Matsumura T
        • Onishi H
        • Inoue K
        • et al.
        Neuroleptic malignant syndrome and hydroxylase gene mutations: no association with CYP2D6A or B.
        Psychiatr. Genet. 1997; 7: 127-129
        • Armstrong M
        • Fairbrother K
        • Idle J.R
        • Daly A.K
        The cytochrome P450 CYP2D6 allelic variant CYP2D6J and related polymorphisms in a European population.
        Pharmacogenetics. 1994; 4: 73-81
        • Gonzalez F.J
        • Idle J.R
        Pharmacogenetic phenotyping and genotyping: present status and future potential.
        Clin. Pharmacokinet. 1994; 26: 59-70
        • Sexena R
        • Shaw G.L
        • Relling M.V
        • Frame J.N
        • Moir D.T
        • Evans W.E
        • Caporaso N
        • Weiffenbach B
        Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype.
        Hum. Mol. Genet. 1994; 3: 923-926
        • Dahl M.-L
        • Bertilsson L
        Genetically variable metabolism of antidepressants and neuroleptic drugs in man.
        Pharmacogenetics. 1993; 3: 61-70
        • Broly F
        • Gaedigk A
        • Heim M
        • Eichelbaum M
        • Morike K
        • Meyer U.A
        Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population.
        DNA Cell. Biol. 1991; 10: 545-558