Magnetic resonance (MR) and 11C-N-methylspiperone (11C-NMSP)/positron emission tomography (PET) imagings were repeatedly performed in a 50-year-old man with the interval form of carbon monoxide (CO) poisoning. In MR images obtained when delayed neuropsychiatric symptoms developed (two months after poisoning), the inner segments of the bilateral globus pallidus appeared as high signal intensities in the T1-weighted and low signal intensities in the T2-weighted images, suggesting prior focal hemorrhage in these areas. A PET study with 11C-NMSP performed at that time showed an increase in dopamine D2 receptor binding in the caudate and putamen. Treatment with bromocriptine was very effective and five months after the poisoning, MR and 11C-NMSP/PET images showed improvement, concomitantly with the disappearance of the neuropsychiatric symptoms.
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Accepted: June 22, 1998
Received in revised form: May 15, 1998
Received: December 23, 1997
© 1998 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.