Highlights
- •Secondary dystonia may follow in patients with parenchymal brain tumors.
- •Hemidystonia is the most common presentation in patients with brain tumors.
- •Dystonia developed in patients with slow growth tumors (WHO I or II).
- •Basal ganglia, thalamus and cortex were the most common sites of brain tumors with dystonia.
- •Dystonia may improve, persist, re-emerge or develop following treatment of brain tumors.
Abstract
Background
Secondary dystonia has been associated with diverse etiologies. Dystonia associated
with brain tumors has not been well characterized.
Objectives
To characterize dystonia and relationship with parenchymal brain tumors.
Methods
We present six patients (1.03%) with dystonia related to parenchymal brain tumors,
among 580 screened cases.
Results
Contralateral hemidystonia was observed in four cases, followed by focal limb (n = 1) and cervical dystonia (n = 1). Dystonia presented during the phase of tumor growth in four cases, and following
tumor treatment in two, one case had re-emergent dystonia. Tumors were low-grade (WHO
I or II) and located in the basal ganglia (n = 3), cortical areas (n = 2), thalamus (n = 1) and cerebral peduncle (n = 1).
Conclusions
Secondary dystonia may be caused by brain tumors in diverse locations including basal
ganglia, cortex and thalamus. It may be the presenting symptom of brain tumor or follow
surgical resection combined with ancillary therapy.
Keywords
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Article info
Publication history
Published online: January 31, 2023
Accepted:
January 27,
2023
Received in revised form:
December 20,
2022
Received:
October 9,
2022
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
