Francisco J. Quintana. Harvard Medical School and The Broad Institute of MIT and Harvard
Astrocytes play important roles in the central nervous system (CNS) during health
and disease. In particular, it is now know that astrocytes play important roles in
CNS inflammation and neurodegeneration in MS and other neurologic diseases. Thus,
the identification of factors that regulate astrocyte activity may shed light on CNS
physiology and guide new therapies for human neurologic disorders. In this presentation
we will discuss mechanisms used by astrocytes to control CNS pathology. In addition,
we will discuss molecular pathways involved in the control of astrocyte function.
For example, we recently found that microbial metabolites limit astrocyte pathogenic
activities in the context of CNS inflammation, while environmental factors can boost
these disease promoting activities. Finally, we will review ongoing efforts on the
characterization of astrocyte heterogeneity in MS, and novel findings on how specific
subsets and their interactions participate in MS pathology.
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