Migraine pathophysiology, clinical correlates

  • Fabiola Dach
    University of Sao Paulo, School of Medicine of Ribeirao Preto, Department of Neuroscience and Behavioral Science, Division of Neurology, Ribeirao Preto, Brazil
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      Migraine is well known by the headache itself, however there are many other signals and symptoms that can occur during an attack. Some symptoms, called premonitory symptoms, such as yawning and feeling tired, occur in 72–84% of patients. About 20% of migraineurs present aura. The most common aura is visual disturbances, following by sensitive symptoms. The headache of migraine is characterized by pulsatile unilateral pain, of moderate to severe intensity, that worsen by routine physical activities, associated with photo/phonofobia, nausea and vomiting. About 68–80% of migraine patients present the last phase called postdrome or resolution, in which the most common symptoms are tiredness and cognitive difficulties. This lecture will discuss the pathophysiological aspects of the main signals and symptoms of a migraine attack.
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