GUT-brain axis

      In humans, epidemiological studies suggest that fetuses' exposure to maternal inflammation increases the likelihood of developing Autism Spectrum Disorder (ASD). We previously demonstrated that interleukin-17a (IL-17a) produced by Th17 cells (CD4+ T helper effector cells involved in multiple autoimmune and inflammatory diseases) is required in pregnant mice to induce behavioral abnormalities in offspring exposed to maternal immune activation (MIA). Furthermore, we and others showed that MIA-induced phenotypes in offspring require maternal intestinal bacteria that promote Th17 cell differentiation. Pregnant mice colonized with a mouse or human commensal bacteria inducing intestinal Th17 cells were more likely to produce offspring with MIA-associated behavioral abnormalities. These and our more recent data suggest that the immune system and its modulation by the gut microbiota might impact the developing brain and potentially the adult brain to shape animal behavior. I will discuss our ongoing efforts to decipher gut bacteria's modulatory roles in affecting brain function.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect