The “hypointense substantia nigra” sign. A novel MRI marker of progressive supranuclear palsy

Published:December 20, 2020DOI:


      • The “hypointense substantia nigra sign” (HSNS) is a novel MRI sign present in PSP.
      • The HSNS is a well-defined hypointense area at the medial substantia nigra in T1 images.
      • The HSNS is highly specific for progressive supranuclear palsy (PSP).
      • The HSNS is more specific but less sensitive for PSP compared to the “Hummingbird sign”.



      PSP (progressive supranuclear pasly), NPH (normal pressure hydrocephalus), HSN (hypointense substatnia nigra), PD (Parkinson's disease), MSA (multiple system atrophy), CBD (corticobasal degeneration), PSP-HSN (PSP with HSN sign), PSP-nHSN (PSP without HSN sign), SN (substantia nigra), SNr (substantia nigra pars reticulata), SNc (substantia nigra pars compacta.)
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