Optic neuritis: Both eyes improve after corticotropin

Published:October 30, 2019DOI:https://doi.org/10.1016/j.jns.2019.116504
      In this issue, Bryan and Sergott [
      • Bryan M.S.
      • Sergott R.C.
      Changes in visual acuity and retinal structures following repository corticotropin injection in patients with acute demyelinating optic neuritis, improvement in low contrast visual acuity in both affected and contralateral eye in a single-armed open-label study.
      ] present extended follow-up of isolated, acute optic neuritis (AON) following treatment with repository corticotropin injection (RCI). Employing modern techniques measuring low contrast visual acuity (LCVA) and retinal anatomy with spectral domain optical coherence tomography (SDOCT), this small, observational, uncontrolled, single-arm study, is significant in scope and findings, enlarging our concept of the events surrounding recovery from optic neuritis. To understand the significance of this report's findings, we review salient anatomy, pathology, prior clinical AON studies, and pharmacology.
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