Only pathogenic variants in protein-coding mtDNA genes cause Leigh syndrome

Published:September 12, 2019DOI:https://doi.org/10.1016/j.jns.2019.116447
      With interest we read the article by Mani et al. about 165 patients with thiamin-responsive Leigh syndrome in whom 100 non-synonymous mtDNA variants in protein-coding mtDNA genes were detected [
      • Mani S.
      • Rao S.N.
      • Kranthi Kumar M.V.
      Genetic heterogeneity of mitochondrial genome in thiamine deficient Leigh syndrome patients.
      ]. We have the following comments and concerns.
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