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Letter to the Editor| Volume 404, P16-18, September 15, 2019

Analysis of the TMEM230 gene in familial Parkinson's disease from south Italy

  • Author Footnotes
    1 These authors contributed equally to this work.
    Radha Procopio
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Institute of Molecular Bioimaging and Physiology, National Research Council, Section of Germaneto, Catanzaro, Italy

    Institute of Neurology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Monica Gagliardi
    Correspondence
    Corresponding author at: Institute of Molecular Bioimaging and Physiology - National Research Council, Section of Germaneto (CZ), University Magna Graecia, V.le Europa, 88100 Catanzaro, Italy.
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Institute of Molecular Bioimaging and Physiology, National Research Council, Section of Germaneto, Catanzaro, Italy
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  • Giuseppe Nicoletti
    Affiliations
    Institute of Molecular Bioimaging and Physiology, National Research Council, Section of Germaneto, Catanzaro, Italy
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  • Maurizio Morelli
    Affiliations
    Institute of Neurology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
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  • Grazia Annesi
    Affiliations
    Institute of Molecular Bioimaging and Physiology, National Research Council, Section of Germaneto, Catanzaro, Italy
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  • Aldo Quattrone
    Affiliations
    Institute of Molecular Bioimaging and Physiology, National Research Council, Section of Germaneto, Catanzaro, Italy

    Neuroscience Research Center, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
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  • Author Footnotes
    1 These authors contributed equally to this work.
Published:July 12, 2019DOI:https://doi.org/10.1016/j.jns.2019.07.017
Analysis of the TMEM230 gene in familial Parkinson's disease from south Italy
Previous ArticleBurden of non-motor symptoms in unclear parkinsonism and tremor: A study with [123I]FP-CIT SPECT
Next ArticleAn autopsy case of MM2-thalamic subtype of sporadic Creutzfeldt-Jakob disease with Lewy bodies presenting as a sleep disorder mimicking anti-IgLON5 disease

      Highlights

      • •
        Parkinson’s disease (PD) is the second most common neurodegenerative disorder.
      • •
        Recently, Deng et al. identified a new gene (TMEM230) in a large Canadian Mennonite family with PD.
      • •
        We evaluate the presence of TMEM230 mutations in a cohort of 168 familial PD and 500 control subjects from South Italy.
      • •
        We found a rare missense variant (p.Ile125Met) in a 64-years old woman and four synonymous variant in our population.
      • •
        Other studies are needed to clarify the role of the TMEM230 gene in the pathogenesis of Parkinson’s disease.

      Keywords

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      Article info

      Publication history

      Published online: July 12, 2019
      Accepted: July 11, 2019
      Received in revised form: June 13, 2019
      Received: April 5, 2019

      Identification

      DOI: https://doi.org/10.1016/j.jns.2019.07.017

      Copyright

      © 2019 Elsevier B.V. All rights reserved.

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