Highlights
- •Continuous apomorphine infusion represents an established treatment for advanced Parkinson's Disease (PD).
- •Acute lethargy was repeatedly observed following abrupt apomorphine withdrawal.
- •Profound lethargy was not associated to severe akinetic state and was solved only after restoring apomorphine.
- •Lethargy might be a symptom of acute apomorphine withdrawal.
Keywords
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References
- Expert Consensus Group report on the use of apomorphine in the treatment of Parkinson’s disease—clinical practice recommendations.Parkinsonism Relat. Disord. 2015; 21: 1023-1030
- Acute akinesia in Parkinson disease.Neurology. 2005; 64: 1162-1169
- Dopamine agonist withdrawal syndrome in Parkinson disease.Arch. Neurol. 2010; 67: 58-63
- Addiction-like manifestations and Parkinson’s disease: a large single center 9-year experience.Int. J. Neurosci. 2012; 122: 145-153
- Awakenings.Duckworth, London1973
- Apathy and impulse control disorders: yin & Yang of dopamine dependent Behaviors.J. Park. Dis. 2015; 5: 625-636
- Long-term effects of levodopa in the severely disabled patient.JAMA. 1970; 213: 2270
- Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole.Neurology. 1999; 52: 1908-1910
- Sleep disorders in Parkinson’s disease: a narrative review of the literature.Rev. Neurosci. 2013; 24: 279-291
- Psychostimulant effect of dopaminergic treatment and addictions in Parkinson’s disease.Mov. Disord. 2017; 32: 1566-1573
- Amphetamine abuse. Pattern and effects of high doses taken intravenously.JAMA. 1967; 201: 305-309
- Treatment for amphetamine withdrawal. Cochrane Database Of Systematic Reviews.2009 (Issue 2. Art. No.:CD003021)
- Amantadine, apomorphine and zolpidem in the treatment of disorders of consciousness.Curr. Pharm. Des. 2014; 20: 4167-4184
- Recovery of consciousness after brain injury: a mesocircuit hypothesis.Trends Neurosci. 2010; 33: 1-9
- Apomorphine - pharmacological properties and clinical trials in Parkinson’s disease.Parkinsonism Relat. Disord. 2016; 33: S13-S21
Article info
Publication history
Published online: July 10, 2019
Accepted:
July 9,
2019
Received in revised form:
June 4,
2019
Received:
March 27,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
