Advertisement
Letter to the Editor| Volume 404, P36-39, September 15, 2019

An autopsy case of MM2-thalamic subtype of sporadic Creutzfeldt-Jakob disease with Lewy bodies presenting as a sleep disorder mimicking anti-IgLON5 disease

Published:July 10, 2019DOI:https://doi.org/10.1016/j.jns.2019.07.010
An autopsy case of MM2-thalamic subtype of sporadic Creutzfeldt-Jakob disease with Lewy bodies presenting as a sleep disorder mimicking anti-IgLON5 disease
Previous ArticleAnalysis of the TMEM230 gene in familial Parkinson's disease from south Italy
Next ArticleVanishing midbrain mass lesion - A germinoma?

      Highlights

      • •
        We report a case of MM2-thalamic-sCJD presenting as a sleep disorder mimicking anti-IgLON5 disease.
      • •
        Post-mortem analysis of brain tissue showed MM2-thalamic-sCJD with Lewy bodies (LB).
      • •
        MM2-thalamic-sCJD with LB should be considered as a differential diagnosis of sleep disorder mimicking anti-IgLON5 disease.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Parchi P.
        • Giese A.
        • Capellari S.
        • Brown P.
        • Schulz-Schaeffer W.
        • Windl O.
        • et al.
        Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects.
        Ann. Neurol. 1999; 46: 224-233
        View in Article
        • Hamaguchi T.
        • Kitamoto T.
        • Sato T.
        • Mizusawa H.
        • Nakamura Y.
        • Noguchi M.
        • et al.
        Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease.
        Neurology. 2005; 64: 643-648
        View in Article
        • Cortelli P.
        • Perani D.
        • Montagna P.
        • Gallassi R.
        • Tinuper P.
        • Provini F.
        • et al.
        Pre-symptomatic diagnosis in fatal familial insomnia: serial neurophysiological and 18FDG-PET studies.
        Brain. 2006; 129: 668-675
        View in Article
        • Sabater L.
        • Gaig C.
        • Gelpi E.
        • Bataller L.
        • Lewerenz J.
        • Torres-Vega E.
        • et al.
        A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study.
        Lancet Neurol. 2014; 13: 575-586
        View in Article
        • Gaig C.
        • Graus F.
        • Compta Y.
        • Hogl B.
        • Bataller L.
        • Bruggemann N.
        • et al.
        Clinical manifestations of the anti-IgLON5 disease.
        Neurology. 2017; 88: 1736-1743
        View in Article
        • Iranzo A.
        • Santamaria J.
        • Tolosa E.
        The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases.
        Sleep Med. Rev. 2009; 13: 385-401
        View in Article
        • Atarashi R.
        • Satoh K.
        • Sano K.
        • Fuse T.
        • Yamaguchi N.
        • Ishibashi D.
        • et al.
        Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.
        Nat. Med. 2011; 17: 175-178
        View in Article
        • McKeith I.G.
        • Dickson D.W.
        • Lowe J.
        • Emre M.
        • O'Brien J.T.
        • Feldman H.
        • et al.
        Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium.
        Neurology. 2005; 65: 1863-1872
        View in Article
        • Abu-Rumeileh S.
        • Redaelli V.
        • Baiardi S.
        • Mackenzie G.
        • Windl O.
        • Ritchie D.L.
        • et al.
        Sporadic fatal insomnia in Europe: phenotypic features and diagnostic challenges.
        Ann. Neurol. 2018; 84: 347-360
        View in Article
        • Montagna P.
        • Gambetti P.
        • Cortelli P.
        • Lugaresi E.
        Familial and sporadic fatal insomnia.
        Lancet Neurol. 2003; 2: 167-176
        View in Article
        • Iwata S.
        • Nakamura A.
        • Nakamura N.
        • Sakashita I.
        • Fukunaga H.
        2 cases of Creutzfeldt-Jacob disease with bilateral vocal cord paralysis.
        Rinsho Shinkeigaku. 1988; 28: 333-337
        View in Article

      Article info

      Publication history

      Published online: July 10, 2019
      Accepted: July 9, 2019
      Received in revised form: June 15, 2019
      Received: March 29, 2019

      Identification

      DOI: https://doi.org/10.1016/j.jns.2019.07.010

      Copyright

      © 2019 Elsevier B.V. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX