Parkinson's disease (PD) is the second most common neurodegenerative disease with
an incidence of 1 in 100 people over 50 years of age. Most common symptoms seen in
this population are related to the motor system, but with increased awareness of non-motor
symptoms (NMS),such as anxiety, depression, stress, fatigue, behavioral changes, sensory
and sleep abnormalities are also being reported frequently, including anxiety, depression,
stress, fatigue, behavioral changes, sensory and sleep abnormalities have been reported
[
[1]
]. These symptoms need special consideration as these symptoms may exaggerate the
motor symptoms. We are grateful to Espay et al. [
[2]
] for their recently published article entitled, ‘Lack of independent mood-enhancing effect for dopaminergic medications in early Parkinson's
disease’ in Journal of the neurological sciences. They found that motor symptoms can get exaggerated with depression in these patients,
dopamine agonist (DA) have no beneficial effect in the treatment of depression, and
need of an additional medication class to treat depression in this population. This
research is a significant contribution to science literature.Keywords
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References
- What a neurologist should know about depression in Parkinson’s disease.Pract. Neurol. 2017; 17: 359-368https://doi.org/10.1136/practneurol-2017-001650
- Lack of independent mood-enhancing effect for dopaminergic medications in early Parkinson’s disease.J. Neurol. Sci. 2019; 402: 81-85https://doi.org/10.1016/j.jns.2019.05.009
- Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system.Brain. 2005; 128: 1314-1322https://doi.org/10.1093/brain/awh445
- Dopaminergic therapies for non-motor symptoms in Parkinson’s disease.CNS Drugs. 2017; 31: 551-570https://doi.org/10.1007/s40263-017-0450-z
- Early life stress, depression and Parkinson’s disease: a new approach.Mol. Brain. 2018; 11: 18https://doi.org/10.1186/s13041-018-0356-9
- Efficacy of antidepressive medication for depression in Parkinson disease: a network meta-analysis.Medicine. 2017; 96https://doi.org/10.1097/MD.0000000000006698
- A systematic review and meta-analysis of cognitive behavioral and psychodynamic therapy for depression in Parkinson’s disease patients.Neurol. Sci. 2015; 36: 833-843https://doi.org/10.1007/s10072-015-2118-0
Article info
Publication history
Published online: July 09, 2019
Accepted:
June 26,
2019
Received:
June 22,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
