Advertisement

Varicella-zoster virus vasculopathy in a multiple sclerosis patient on fingolimod

  • Author Footnotes
    1 These authors contributed equally to the manuscript.
    Alexandra Muccilli
    Footnotes
    1 These authors contributed equally to the manuscript.
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada

    Department of Neurology, University of California, San Francisco, United States of America
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to the manuscript.
    Ahmad Nehme
    Correspondence
    Corresponding author at: Centre Hospitalier de l'Université de Montréal, 1051 Rue Sanguinet, Montreal, Quebec H2X 3E4, Canada.
    Footnotes
    1 These authors contributed equally to the manuscript.
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
    Search for articles by this author
  • Marilyn Labrie
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
    Search for articles by this author
  • Marc Girard
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
    Search for articles by this author
  • Celine Odier
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
    Search for articles by this author
  • Alexandre Y. Poppe
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to the manuscript.

      Highlights

      • Fingolimod treatment may be associated with VZV vasculopathy in MS patients.
      • Fingolimod related VZV vasculopathy can develop in the absence of prior shingles.
      • Lymphopenia is a risk factor for fingolimod-associated VZV reactivation.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Ratchford J.N.
        • Costello K.
        • Reich D.S.
        • et al.
        Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod.
        Neurology. 2012; 79: 2002-2004
        • Lanthier S.
        • Armstrong D.
        • Domi T.
        • et al.
        Post-varicella arteriopathy of childhood: natural history of vascular stenosis.
        Neurology. 2005; 64: 660-663
        • Sundström K.
        • Weibull C.E.
        • Söderber-Löfdal K.
        • et al.
        Incidence of herpes zoster and associated events including stroke - a population-based cohort study.
        BMC Infect. Dis. 2015; 15: 488
        • Nagel M.A.
        • Cohrs R.J.
        • Mahalingam R.
        • et al.
        The varicella zoster virus vasculopathies: clinical, CSF, imaging and virologic features.
        Neurology. 2008; 70: 853-860
        • Cheng-Ching E.
        • Jones S.
        • Hui F.K.
        • et al.
        High-resolution MRI vessel wall imaging in varicella zoster virus vasculopathy.
        J. Neurol. Sci. 2015; 351: 168-173
        • Francis G.
        • Kappos L.
        • O'Connor P.
        • et al.
        Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy.
        Mult. Scler. 2014; 20: 471-480
        • Mehling M.
        • Brinkmann V.
        • Antel J.
        • et al.
        FYT720 therapy exerts differential effects on T cell subsets in multiple sclerosis.
        Neurology. 2008; 71: 1261-1267
        • Arvin A.M.
        • Wolinsky J.S.
        • Kappos L.
        • et al.
        Varicella-zoster virus infections in patients treated with fingolimod: risk assessment and consensus recommendations for management.
        JAMA Neurol. 2015; 72: 31-39