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Letter to the Editor| Volume 403, P119-121, August 15, 2019

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Varicella-zoster virus vasculopathy in a multiple sclerosis patient on fingolimod

  • Author Footnotes
    1 These authors contributed equally to the manuscript.
    Alexandra Muccilli
    Footnotes
    1 These authors contributed equally to the manuscript.
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada

    Department of Neurology, University of California, San Francisco, United States of America
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to the manuscript.
    Ahmad Nehme
    Correspondence
    Corresponding author at: Centre Hospitalier de l'Université de Montréal, 1051 Rue Sanguinet, Montreal, Quebec H2X 3E4, Canada.
    Footnotes
    1 These authors contributed equally to the manuscript.
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
    Search for articles by this author
  • Marilyn Labrie
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
    Search for articles by this author
  • Marc Girard
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
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  • Celine Odier
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
    Search for articles by this author
  • Alexandre Y. Poppe
    Affiliations
    Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Québec, Canada
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to the manuscript.
Published:June 26, 2019DOI:https://doi.org/10.1016/j.jns.2019.06.025
Varicella-zoster virus vasculopathy in a multiple sclerosis patient on fingolimod
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      Highlights

      • •
        Fingolimod treatment may be associated with VZV vasculopathy in MS patients.
      • •
        Fingolimod related VZV vasculopathy can develop in the absence of prior shingles.
      • •
        Lymphopenia is a risk factor for fingolimod-associated VZV reactivation.

      Keywords

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      References

        • Ratchford J.N.
        • Costello K.
        • Reich D.S.
        • et al.
        Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod.
        Neurology. 2012; 79: 2002-2004
        View in Article
        • Lanthier S.
        • Armstrong D.
        • Domi T.
        • et al.
        Post-varicella arteriopathy of childhood: natural history of vascular stenosis.
        Neurology. 2005; 64: 660-663
        View in Article
        • Sundström K.
        • Weibull C.E.
        • Söderber-Löfdal K.
        • et al.
        Incidence of herpes zoster and associated events including stroke - a population-based cohort study.
        BMC Infect. Dis. 2015; 15: 488
        View in Article
        • Nagel M.A.
        • Cohrs R.J.
        • Mahalingam R.
        • et al.
        The varicella zoster virus vasculopathies: clinical, CSF, imaging and virologic features.
        Neurology. 2008; 70: 853-860
        View in Article
        • Cheng-Ching E.
        • Jones S.
        • Hui F.K.
        • et al.
        High-resolution MRI vessel wall imaging in varicella zoster virus vasculopathy.
        J. Neurol. Sci. 2015; 351: 168-173
        View in Article
        • Francis G.
        • Kappos L.
        • O'Connor P.
        • et al.
        Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy.
        Mult. Scler. 2014; 20: 471-480
        View in Article
        • Mehling M.
        • Brinkmann V.
        • Antel J.
        • et al.
        FYT720 therapy exerts differential effects on T cell subsets in multiple sclerosis.
        Neurology. 2008; 71: 1261-1267
        View in Article
        • Arvin A.M.
        • Wolinsky J.S.
        • Kappos L.
        • et al.
        Varicella-zoster virus infections in patients treated with fingolimod: risk assessment and consensus recommendations for management.
        JAMA Neurol. 2015; 72: 31-39
        View in Article

      Article info

      Publication history

      Published online: June 26, 2019
      Accepted: June 24, 2019
      Received in revised form: June 14, 2019
      Received: May 26, 2019

      Identification

      DOI: https://doi.org/10.1016/j.jns.2019.06.025

      Copyright

      © 2019 Elsevier B.V. All rights reserved.

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