Ciguatera poisoning is a widespread seafood-toxic illness, endemic in the tropical
and subtropical regions of Caribbean and Indo-Pacific. It is the most frequently reported
marine toxin-related poisoning globally. The climate and environment changes together
with the international commerce and consumption of frozen fish species are responsible
for an increasing number of Ciguatera poisoning also in temperate regions [
[1]
]. Ciguatoxins are produced by dinoflagellates of the Gambierdiscus species, bottom-dwelling
single-cell organisms living in the coral reef. Ciguatoxins are lipophilic, soluble,
heat-stable polycyclic polyethers, which are stored in finfish viscera and concentrate
and bioaccumulate up the food chain from small reef fish to the large carnivorous
species. They are grouped in 3 variants, depending on their origin from the Pacific
(P-CTX), Caribbean (C-CTX) and Indian Ocean (I-CTX) [
[2]
].Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countries.Toxicon. 2014; 91: 76-83https://doi.org/10.1016/j.toxicon.2014.10.016
- Ciguatera: a public health perspective.Toxicon. 2010; 56: 123-136https://doi.org/10.1016/j.toxicon.2009.09.008
- Ciguatera poisoning.Pract. Neurol. 2007; 7: 316-322https://doi.org/10.1136/jnnp.2007.129049
- An updated review of ciguatera fish poisoning: clinical, epidemiological, environmental, and public health management.Mar. Drugs. 2017; 15: 72https://doi.org/10.3390/md15030072
- Clinical observations on 3,009 cases of ciguatera (fish poisoning) in the South Pacific.Am. J. Trop. Med. Hyg. 1979; 28: 1067-1073
- Differential actions of Pacific ciguatoxin-1 on sodium channel subtypes in mammalian sensory neurons.J. Pharmacol. Exp. Ther. 1999; 288: 379-388
- Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.EMBO J. 2012; 31: 3795-3808https://doi.org/10.1038/emboj.2012.207
- Ciguatoxins evoke potent CGRP release by activation of voltage-gated sodium channel subtypes NaV1.9, NaV1.7 and NaV1.1.Mar. Drugs. 2017; 15: 269https://doi.org/10.3390/md15090269
- Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury.Sci. Rep. 2016; 6https://doi.org/10.1038/srep26809
- Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies.Neurology. 2003; 61: 631-636
Article info
Publication history
Published online: June 20, 2019
Received in revised form:
June 12,
2019
Received:
March 24,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
