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Predictors of respiratory impairment in patients with myotonic dystrophy type 1

      Rossi et al. conducted a cross-sectional study to evaluate predictors of respiratory impairment in 268 patients with myotonic dystrophy type 1 (DM1) [
      • Rossi S.
      • Della Marca G.
      • Ricci M.
      • Perna A.
      • Nicoletti T.F.
      • Brunetti V.
      • Meleo E.
      • Calvello M.
      • Petrucci A.
      • Antonini G.
      • Bucci E.
      • Licchelli L.
      • Sancricca C.
      • Massa R.
      • Rastelli E.
      • Botta A.
      • Di Muzio A.
      • Romano S.
      • Garibaldi M.
      • Silvestri G.
      Prevalence and predictor factors of respiratory impairment in a large cohort of patients with Myotonic Dystrophy type 1 (DM1): A retrospective, cross sectional study.
      ]. Restrictive respiratory syndrome (respiratory impairment) was defined as forced vital capacity (FVC) <80%, and 139 patients (51.9%) showed having impairment. In multivariate analysis, score of muscular impairment rating scale (MIRS) and mean cytosine-thymine-guanine nucleotide (CTG)n values in leukocytes were selected as significant predictors for respiratory impairment. They concluded that the severity of muscle impairment and the CTG expansion size were confirmed as important predictors of respiratory impairment. I have some concerns about their study.

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      References

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        • Della Marca G.
        • Ricci M.
        • Perna A.
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        • Brunetti V.
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        Prevalence and predictor factors of respiratory impairment in a large cohort of patients with Myotonic Dystrophy type 1 (DM1): A retrospective, cross sectional study.
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