Rossi et al. conducted a cross-sectional study to evaluate predictors of respiratory
impairment in 268 patients with myotonic dystrophy type 1 (DM1) [
[1]
]. Restrictive respiratory syndrome (respiratory impairment) was defined as forced
vital capacity (FVC) <80%, and 139 patients (51.9%) showed having impairment. In multivariate
analysis, score of muscular impairment rating scale (MIRS) and mean cytosine-thymine-guanine
nucleotide (CTG)n values in leukocytes were selected as significant predictors for
respiratory impairment. They concluded that the severity of muscle impairment and
the CTG expansion size were confirmed as important predictors of respiratory impairment.
I have some concerns about their study.- Rossi S.
- Della Marca G.
- Ricci M.
- Perna A.
- Nicoletti T.F.
- Brunetti V.
- Meleo E.
- Calvello M.
- Petrucci A.
- Antonini G.
- Bucci E.
- Licchelli L.
- Sancricca C.
- Massa R.
- Rastelli E.
- Botta A.
- Di Muzio A.
- Romano S.
- Garibaldi M.
- Silvestri G.
Prevalence and predictor factors of respiratory impairment in a large cohort of patients
with Myotonic Dystrophy type 1 (DM1): A retrospective, cross sectional study.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Prevalence and predictor factors of respiratory impairment in a large cohort of patients with Myotonic Dystrophy type 1 (DM1): A retrospective, cross sectional study.J. Neurol. Sci. 2019; 399: 118-124https://doi.org/10.1016/j.jns.2019.02.012
- Respiratory dysfunction in myotonic dystrophy type 1: A systematic review.Neuromuscul. Disord. 2019; 29: 198-212https://doi.org/10.1016/j.nmd.2018.12.002
- Longitudinal course of lung function in myotonic dystrophy type 1.Muscle Nerve. 2017; 56: 816-818https://doi.org/10.1002/mus.25604
Article Info
Publication History
Published online: May 23, 2019
Accepted:
May 22,
2019
Received:
April 23,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
