- •Acute intermittent porphyria is a disorder of heme metabolism caused by genetic mutation in porphobilinogen deaminase.
- •Accumulation of toxic heme precursors leads to a variety of systemic and neurological symptoms.
- •Peripheral nervous system manifestations include recurrent axonal polyradiculoneuropathy.
- •Triggers include smoking, alcohol, anti epileptics, hormone supplements and barbiturates.
- •Prompt treatment of acute attacks by glucose and hematin infusions.
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