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Research Article| Volume 398, P142-147, March 15, 2019

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Clinical, neuropsychological and imaging characteristics of Alzheimer's disease patients presenting as corticobasal syndrome

  • Vasilios C. Constantinides
    Correspondence
    Corresponding author at: Eginition Hospital, 72-74 Vas. Sophias Ave., 11528 Athens, Greece.
    Affiliations
    1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece, 72-74 Vas. Sophias Ave., 11528 Athens, Greece
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  • George P. Paraskevas
    Affiliations
    1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece, 72-74 Vas. Sophias Ave., 11528 Athens, Greece
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  • Efthymia Efthymiopoulou
    Affiliations
    1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece, 72-74 Vas. Sophias Ave., 11528 Athens, Greece
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  • Leonidas Stefanis
    Affiliations
    1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece, 72-74 Vas. Sophias Ave., 11528 Athens, Greece
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  • Elisabeth Kapaki
    Affiliations
    1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece, 72-74 Vas. Sophias Ave., 11528 Athens, Greece
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Published:January 29, 2019DOI:https://doi.org/10.1016/j.jns.2019.01.046

      Highlights

      • CSF analysis can differentiate CBS-AD from CBS non-AD patients.
      • 30% of CBS patients have an underlying AD pathology.
      • Alien hand phenomena are more common in CBS-AD patients.
      • Clinical and imaging features cannot safely differentiate CBS-AD from CBS-nAD.

      Abstract

      Background

      Corticobasal syndrome (CBS) can harbor diverse pathologies, such as corticobasal degeneration (CBD) and Alzheimer's disease (AD). CSF biochemical analysis in CBS patients can confidently distinguish between an AD (CBS-AD) and a non-AD (CBS-nAD) pathology.

      Objective

      We utilized classical CSF biomarkers to make a distinction between the two groups and examine their clinical, neuropsychological, neuropsychiatric and imaging differences.

      Methods

      Seventeen patients with a CBS phenotype were included. Detailed clinical history, and neurological examination data were recorded. A thorough neuropsychological and neuropsychiatric test battery was performed, including Goldenberg apraxia test. Simple linear MRI measurements and planimetry data were utilized. CSF biomarkers for AD were ascertained.

      Results

      Five of seventeen CBS patients had a CSF AD profile. Patients with a CSF AD profile (CBS-AD; n = 5) were older and had a greater age at disease onset compared to CBS-nAD. CBS-AD patients had more frequently alien hand phenomena at examination and greater hippocampi surface asymmetry at MRI. CBS-nAD patients (n = 12) had lower superior colliculi width values.

      Conclusion

      Clinical, neuropsychological and imaging data cannot confidently differentiate CBS-AD from CBS-nAD patients.

      Keywords

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