Highlights
- •CSF analysis can differentiate CBS-AD from CBS non-AD patients.
- •30% of CBS patients have an underlying AD pathology.
- •Alien hand phenomena are more common in CBS-AD patients.
- •Clinical and imaging features cannot safely differentiate CBS-AD from CBS-nAD.
Abstract
Background
Corticobasal syndrome (CBS) can harbor diverse pathologies, such as corticobasal degeneration
(CBD) and Alzheimer's disease (AD). CSF biochemical analysis in CBS patients can confidently
distinguish between an AD (CBS-AD) and a non-AD (CBS-nAD) pathology.
Objective
We utilized classical CSF biomarkers to make a distinction between the two groups
and examine their clinical, neuropsychological, neuropsychiatric and imaging differences.
Methods
Seventeen patients with a CBS phenotype were included. Detailed clinical history,
and neurological examination data were recorded. A thorough neuropsychological and
neuropsychiatric test battery was performed, including Goldenberg apraxia test. Simple
linear MRI measurements and planimetry data were utilized. CSF biomarkers for AD were
ascertained.
Results
Five of seventeen CBS patients had a CSF AD profile. Patients with a CSF AD profile
(CBS-AD; n = 5) were older and had a greater age at disease onset compared to CBS-nAD.
CBS-AD patients had more frequently alien hand phenomena at examination and greater
hippocampi surface asymmetry at MRI. CBS-nAD patients (n = 12) had lower superior
colliculi width values.
Conclusion
Clinical, neuropsychological and imaging data cannot confidently differentiate CBS-AD
from CBS-nAD patients.
Keywords
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Article info
Publication history
Published online: January 29, 2019
Accepted:
January 28,
2019
Received in revised form:
January 23,
2019
Received:
August 30,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.