Advertisement
Letter to the Editor| Volume 398, P131-134, March 15, 2019

Download started.

Ok

Stroke revealing Neuro-Behçet's disease with parenchymal and extensive vascular involvement

Published:January 26, 2019DOI:https://doi.org/10.1016/j.jns.2019.01.044
      The frequency of neurologic manifestations in Behçet's disease (BD) ranges between 5% and 15% [
      • Peño I.C.
      • De lasHerasRevilla V.
      • Carbonell B.P.
      • Di CapuaSacoto D.
      • Ferrer M.E.
      • García-Cobos R.
      • González R.A.
      Neurobehçet disease: clinical and demographiccharacteristics.
      ]. Central nervous system manifestations are represented by parenchymal involvement, which includes brainstem involvement, hemispheric manifestations, spinal cord lesions, and meningo-encephalitic presentations and non parenchymal involvement, including dural sinus thrombosis, arterial occlusion, and/or aneurysms. The association of parenchymal and vascular manifestations is extremely rare [
      • Saadoun D.
      • Asli B.
      • Wechsler B.
      • Houman H.
      • Geri G.
      • Desseaux K.
      • et al.
      Long-term outcome of arterial lesions in Behcet disease: a series of 101 patients.
      ]. Among the neuro-vasculo-Behçet's disease patients, venous thrombosis is well-known while arterial involvement has rarely been reported and seldom concerned cerebral arteries. We describe here a stroke case revealing neuro-Behçet's disease (NBD) with parenchymal involvement and extensive vascular lesions interesting several intracranial and systemic arteries. To the best of our knowledge, this is the first reported case of Behçet's disease manifesting as concomitant involvement of systemic and cerebral arteries.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Peño I.C.
        • De lasHerasRevilla V.
        • Carbonell B.P.
        • Di CapuaSacoto D.
        • Ferrer M.E.
        • García-Cobos R.
        • González R.A.
        Neurobehçet disease: clinical and demographiccharacteristics.
        Eur. J. Neurol. 2012 Sep; 19: 1224-1227
        • Saadoun D.
        • Asli B.
        • Wechsler B.
        • Houman H.
        • Geri G.
        • Desseaux K.
        • et al.
        Long-term outcome of arterial lesions in Behcet disease: a series of 101 patients.
        Medicine (Baltimore). 2012; 91: 18-24
        • Melikoglu M.
        • Kural-Seyahi E.
        • Tascilar K.
        • Yazici H.
        The unique features of vasculitis in Behçet's syndrome.
        Clin. Rev. Allergy Immunol. 2008 Oct; 35: 40-46
        • Leiba M.
        • Seligsohn U.
        • Sidi Y.
        • Harats D.
        • Sela B.A.
        • Griffin J.H.
        • Livneh A.
        • Rosenberg N.
        • Gelernter I.
        • Gur H.
        • Ehrenfeld M.
        Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease.
        Ann. Rheum. Dis. 2004 Nov; 63: 1445-1449
        • Lakhanpal S.
        • Tani K.
        • Lie J.T.
        • Katoh K.
        • Ishigatsubo Y.
        • Ohokubo T.
        Pathologic features of Behcet's syndrome: a review of Japanese autopsy registry data.
        Hum. Pathol. 1985; 16: 790-795
        • Tascilar K.
        • Melikoglu M.
        • Ugurlu S.
        • Sut N.
        • Caglar E.
        • Yazici H.
        Vascular involvement in Behçet's syndrome: a retrospective analysis of associations and the time course.
        Rheumatology (Oxford). 2014 Nov; 53: 2018-2022
        • Yang S.S.
        • Park K.M.
        • Park Y.J.
        • Kim Y.W.
        • Do Y.S.
        • Park H.S.
        • Park K.B.
        • Kim D.I.
        Peripheral arterial involvement in Behcet's disease: an analysis of the results from a Korean referral center.
        Rheumatol Int. 2013 Aug; 33: 2101-2108
        • Desbois A.-C.
        • Wechsler B.
        • Cluzel P.
        • Helft G.
        • Boutin D.
        • Piette J.-C.
        • Cacoub P.
        • Saadoun D.
        Atteintes cardiovasculaires de la maladie de Behcet.
        La Revue de médecine interne. 2014; 35: 103-111
        • Ait Ben Haddou E.
        • Benomar A.
        • Regragui W.
        • Yahyaoui M.
        Amezcua-Guerra Luis M. Neurological Manifestations in Behcet Disease, Advances in the Diagnosis and Treatment of Vasculitis. InTech, 2011 (ISBN: 978-953-307-786-4. Available from: http://www.intechopen.com/books/advances-in-the-diagnosis-andtreatment-of-vasculitis/neurological-manifestations-in-behcet-disease)
        • Desbois A.C.
        • Wechsler B.
        • Cacoub P.
        • Saadoun D.
        Aortic inflammatory lesions in Behcet's disease.
        Rev Med Interne. 2016 Apr; 37: 230-238