Highlights
- •Essential thrombocythemia (ET) is associated with an increased risk of thromboembolism.
- •ET stroke without conventional stroke mechanism displayed multiple embolic patterns.
- •Hemoglobin was inversely correlated with neurological deficit in ET stroke patients.
Abstract
Background
Essential thrombocythemia (ET) is known to be associated with an increased vascular
event, but the stroke patterns and prognosis have not been studied.
Methods
Between January 2013 and December 2017, acute ischemic stroke patients with ET who
were admitted to two tertiary hospital stroke centers in Seoul, Korea were included.
We retrospectively reviewed their clinical, laboratory and imaging data. Stroke mechanism
was determined as ET-only when no atherosclerotic, cardioembolic, or lacunar stroke
etiology was demonstrated and as ET-plus group when any specific etiology was combined.
Each group was analyzed to ascertain stroke patterns and outcomes.
Results
A total of 26 patients were included, and their mean age was 66 ± 17 years, including
12 female patients. There were 12 ET-only cases and 14 ET-plus cases per stroke mechanism.
The ET-plus group included 7 large artery atherosclerosis, 5 small vessel occlusion,
and 2 cardioembolic cases. Multiple scattered lesions involving multiple vascular
territories were more prevalent in the ET-only group. Poor outcome (modified Rankin
scale >2 at discharge) was noted in 13 cases (50.0%), and old age, female sex, prior
diagnosis of ET to stroke and low hemoglobin level were associated with poor outcome.
Conclusion
ET-related stroke displayed a characteristic infarction pattern, such as multiple
embolisms.
Keywords
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References
- Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk-stratification, and management.Am. J. Hematol. 2017; 92: 94-108
- Ischaemic stroke and essential thrombocythemia: a series of 14 cases.Eur. J. Neurol. 2011; 18: 995-998
- Ischemic stroke with essential thrombocythemia: a case series.J. Stroke Cerebrovasc. Dis. 2015; 24: 890-893
- Stroke in essential thrombocythemia.J. Neurol. Sci. 2014; 336: 260-262
- Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.Stroke. 1993; 24: 35-41
- Cryptogenic stroke.N. Engl. J. Med. 2016; 374: 2065-2074
- Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes.Lancet Neurol. 2008; 7: 915-926
- Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review, and meta-analysis.J. Am. Heart Assoc. 2016; 5e003019
Article info
Publication history
Published online: January 22, 2019
Accepted:
January 21,
2019
Received in revised form:
January 17,
2019
Received:
September 3,
2018
Identification
Copyright
© 2019 Published by Elsevier B.V.
