Highlights
- •60% of patients with Parkinson's Disease have one or more psychiatric symptoms.
- •Dopaminergic therapy leads to cognitive and behavioral disorders.
- •These patients have an increased risk in developing impulsive control disorders.
- •The mesolimbic and mesocortical pathways are involved in impulsive control disorders.
Abstract
Aim
Purpose of this review is to evaluate the potential risk factors that may predispose
to the development of Impulse control disorders (ICDs) in Parkinson's Disease (PD)
patients, including the effects of dopaminergic therapy.
Methods
This descriptive review was conducted to identificate risk factors that could cause
impulsive control disorders in PD. Studies were found on PubMed (2010–2018), Web Of
Science (January 2010–July 2018) and Cochrane (2010–2018) databases.
Results
The data suggest that intrinsic and extrinsic factors may be involved in the development
of behavioral complications. To date, the link between PD and the development of ICDs
is not very clear, but studies highlight the existence of a predisposition to ICDs
in the presence of risk factors.
Conclusions
A better assessment of the behavioral disorders of PD may be useful in the rehabilitative
intervention for increasing the quality of life.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Parkinson's disease: a review.Neurol. India. 2018; 66: S26-S35https://doi.org/10.4103/0028-3886.226451
- Epidemiology and etiology of Parkinson's disease: a review of the evidence.Eur. J. Epidemiol. 2011; 26 (S1–58)https://doi.org/10.1007/s10654-011-9581-6
- Clinical spectrum of impulse control disorders in Parkinson's disease.Mov. Disord. 2015; 30: 121-127https://doi.org/10.1002/mds.26016
- Impulse control disorders and related behaviours (ICD-RBs) in Parkinson's disease patients: assessment using "Questionnaire for impulsive-compulsive disorders in Parkinson's disease" (QUIP).Ann. Indian Acad. Neurol. 2015; 18: 49-59https://doi.org/10.4103/0972-2327.144311
- Non pharmacological treatment procedures for Parkinson's disease.Nervenarzt. 2017; 88: 383-390https://doi.org/10.1007/s00115-017-0298-y
- Personal computer-based cognitive training in Parkinson's disease: a casestudy.Psychogeriatrics. 2018; 18: 427-429https://doi.org/10.1111/psyg.12333
- Quantitative analysis of pursuit ocular movements in Parkinson's disease by using a video-based eye tracking system.Eur. Neurol. 2007; 58: 193-197
- The effect of L-Dopa administration on pursuit ocular movements in suspected Parkinson's disease.Neurol. Sci. 2010; 31: 381-385https://doi.org/10.1007/s10072-009-0180-1
- Diagnostic and statistical manual of mental disorders.in: Text Revision. Fifth Ed. Merican Psychiatric Association, Washington2000
- Pathological gambling caused by drugs used to treat Parkinson disease.Arch. Neurol. 2005; 62: 1-5https://doi.org/10.1001/archneur.62.9.noc50009
- Pathological gambling associated with dopamine agonist therapy in Parkinson's disease.Neurology. 2003; 61: 422-423
- Dopamine and impulse control disorders in Parkinson's disease.Ann. Neurol. 2008; 64: S93-100
- Impulse control disorder related behaviours during long-term rotigotine treatment: a post hoc analysis.Eur. J. Neurol. 2016; 23: 1556-1565https://doi.org/10.1111/ene.13078
- Increased risk of impulse control symptoms in Parkinson's disease with REM sleep behaviour disorder.J. Neurol. Neurosurg. 2015; 86: 174-179https://doi.org/10.1136/jnnp-2014-307904
- Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review.Mov. Disord. 2019; https://doi.org/10.1002/mds.27602
- Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies (DRTs).J. Neurol. Neurosurg. Psychiatry. 2000; 68: 423-428
- Compulsive eating and weight gain related to dopamine agonist use.Mov. Disord. 2006; 21: 524-529
- Impulse control disorders in Parkinson disease: a crosssectional study of 3090 patients.Arch. Neurol. 2010; 67: 589-595
- Impulse control disorders and related complications of Parkinson's disease therapy.Semin. Neurol. 2017; 37: 86-192https://doi.org/10.1055/s-0037-1601887
- Impulse control and related disorders in Parkinson's disease.Int. Rev. Neurobiol. 2017; 133: 679-717
- Impulse control and related disorders in Parkinson's disease: review.Ann. NY Acad. Sci. 2008; 1142: 85-107
- Issues for DSM-V: should obesity be included as a brain disorder?.Am. J. Psychiatry. 2007; 164: 708-710https://doi.org/10.1176/ajp.2007.164.5.708
- Dopaminergic neurotransmission in patients with Parkinson's Disease and impulse control disorders: a systematic review and meta-analysis of PET and SPECT studies.Front Neurol. 2018; 9: 1018
- Compulsive buying - a growing concern?An examination of gender, age, and endorsement of materialistic values as predictors.Br. J. Psychol. 2005; 96: 467-491https://doi.org/10.1348/000712605X53533
- Excessive hoarding in Parkinson's disease.Mov. Disord. 2010; 25: 1026-1033https://doi.org/10.1002/mds.23016
- Eating disorders, DSM-5 and clinical reality.Br. J. Psychiatry. 2011; 198: 8-10https://doi.org/10.1192/bjp.bp.110.083881
- Risk factors for pathological gambling.Addict. Behav. 2004; 29: 323-335
- Pathological gambling and depression.Procedia Soc. Behav. Sci. 2013; 78: 501-505https://doi.org/10.1016/j.sbspro.2013.04.339
- Pathological gambling in Parkinson's disease: risk factors and differences from dopamine dysregulation. An analysis of published case series.Mov. Disord. 2007; 22 (10.1002/mds.21611): 1757-1763
- The rise and fall of impulse control behavior disorders.Parkinsonism. Relat. Disord. 2018; 46: S24-S29https://doi.org/10.1016/j.parkreldis.2017.07.030
- Compulsive buying disorder: a review of the evidence.CNS Spectr. 2007; 12: 124-132
- Markers of impaired motor and cognitive volition in Parkinson's disease: correlates of dopamine dysregulation syndrome, impulse control disorder, and dyskinesias.Parkinsonism Relat. Disord. 2018; 2 (30215–3)https://doi.org/10.1016/j.parkreldis.2017.11.338
- Hypersexuality in Parkinson's disease. Advantage of the presence of the entourage for medical assessment.Presse Med. 2015; 44: e51-e58https://doi.org/10.1016/j.lpm.2014.06.037
- Pathological gambling caused by drugs used to treat Parkinson disease.Arch. Neurol. 2005; 62: 1377-1381https://doi.org/10.1001/archneur.62.9.noc50009
- Pathological hypersexuality predominantly linked to adjuvant dopamineagonist therapy in Parkinson's disease and multiple system atrophy.Parkinsonism Relat. Disord. 2005; 11: 381-386https://doi.org/10.1016/j.parkreldis.2005.06.005
- Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients.Arch. Neurol. 2010; 67: 589-595https://doi.org/10.1001/archneurol.2010.65
- Personality and Parkinson's disease: a meta-analysis.Parkinsonism Relat. Disord. 2018; 49: 67-74https://doi.org/10.1016/j.parkreldis.2018.01.013
- Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?.Lancet Neurol. 2003; 2: 595-604https://doi.org/10.1016/S1474-4422(03)00529-5
- Predictors of punding in Parkinson's disease: results from a questionnaire survey.Mov. Disord. 2007; 22: 2339-2345https://doi.org/10.1002/mds.21702
- Compulsive use of dopaminergic drug therapy in Parkinson's disease: reward and anti-reward.Mov. Disord. 2010; 25: 867-876https://doi.org/10.1002/mds.22898
- Clinical features associated with impulse control disorders in Parkinson disease.Neurology. 2006; 67: 1258-1261https://doi.org/10.1212/01.wnl.0000238401.76928.45
- Medication-related impulse control and repetitive behaviors in Parkinson disease.Arch. Neurol. 2007; 64: 1089-1096https://doi.org/10.1001/archneur.64.8.1089
- Impulse control disorders in Chinese Parkinson's disease patients: the effect of ergot derived dopamine agonist.Parkinsonism Relat. Disord. 2011; 17: 635-637https://doi.org/10.1016/j.parkreldis.2011.06.001
- New onset heightened interest or drive for gambling, shopping, eating or sexual activity in patients with Parkinson's disease: the role of dopamine agonist treatment and age at motor symptoms onset.J. Psychopharmacol. 2007; 21: 501-506https://doi.org/10.1177/0269881106073109
- Prevalence and clinical features of hedonistic homeostatic dysregulation in Parkinson's disease.Mov. Disord. 2005; 20: 77-81
- Impulse control disorders in Parkinson disease: a multicenter case - control study.Ann. Neurol. 2011; 69: 986-996https://doi.org/10.1002/ana.22356
- Shared genetic contributions to pathological gambling and major depression in men.Arch. Gen. Psychiatry. 2005; 62: 1015-1021
- Severity of gambling is associated with severity of depressive symptoms in pathological gamblers.Behav. Pharmacol. 2009; 20: 527-536https://doi.org/10.1097/fbp.0b013e3283305e7a
- Age-related differences in levodopa dynamics in Parkinson's: implications for motor complications.Brain. 2006; 129: 1050-1058https://doi.org/10.1093/brain/awl028
- Effects of dopamine agonist dose and gender on the prognosis of impulse control disorders in Parkinson's disease.Parkinsonism Relat. Disord. 2012; 18: 1079-1083https://doi.org/10.1016/j.parkreldis.2012.06.005
- Common genetic vulnerability for pathological gambling and alcohol dependence in men.Arch. Gen. Psychiatry. 2000; 57: 666-673
- Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.J. Clin. Psychol. 2005; 66: 564-574
- Impulsive and compulsive behaviors during dopamine replacement treatment in Parkinson's Disease and other disorders.Curr. Drug Saf. 2012; 7: 63-75
- Personality and problem gambling: a prospective study of a birth cohort of young adults.Arch. Gen. Psychiatry. 2005; 62: 769-775https://doi.org/10.1001/archpsyc.62.7.769
- Age and time course of long-term motor and nonmotor complications in Parkinson disease.Neurology. 2019; 92: e148-e160
- Personality traits in patients with Parkinson'sdisease: assessment and clinical implications.J. Neurol. 2012; 259: 1029-1038https://doi.org/10.1007/s00415-011-6302-8
- Impulse control disorders in Parkinson's disease: definition, epidemiology, risk factors, neurobiology and management.Parkinsonism Relat. Disord. 2009; 15: S111-S115
- Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease.Nat. Clin. Pract. Neurol. 2007; 3: 664-672https://doi.org/10.1038/ncpneuro0680
- Prospective prevalence of pathological gambling and medication association in Parkinson disease.Neurol. 2006; 66: 1750-1752https://doi.org/10.1212/01.wnl.0000218206.20920.4d
- Pathological gambling in Parkinson's disease.BMJ. 2007; 334 (10.1136%2Fbmj.39176.363958.80): 810-811
- Impulse control disorders in patients with Parkinson's disease receiving dopamine replacement therapy: evidence and implications for the addictions field.Addiction. 2011; 106: 283-293https://doi.org/10.1111/j.1360-0443.2010.03218.x
- Estimated prevalence of compulsive buying behavior in the United States.Am. J. Psychtry. 2006; 163: 1806-1812
- Prevalence and correlates of binge eating disorder in a com sample.Compr. Psychiatry. 2007; 48 (10.1016%2Fj.comppsych.2006.08.002): 124-131
- Predictors of impulsivity and reward seeking behavior with DAs.Parkinsonism Relat. Disord. 2008; 14: 28-32https://doi.org/10.1016/j.parkreldis.2007.05.006
- Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex.Neurosci. Biobehav. Rev. 2002; 26: 321-352
- Ventromedial prefrontal cortex damage is associated with decreased ventral striatum volume and response to reward.J. Neurosci. 2016; 36: 5047-5054https://doi.org/10.1523/JNEUROSCI.4236-15.2016
- Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.Nat. Neurosci. 2005; 8: 1481-1489https://doi.org/10.1038/nn1579
- Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior.Neuron. 2010; 66: 896-907https://doi.org/10.1016/j.neuron.2010.05.01
- Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum.Addiction. 2010; 105: 1741-1749https://doi.org/10.1111/j.1360-0443.2010.03022.x
- Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction.J. Neurosci. 2006; 26: 6583-6588https://doi.org/10.1523/JNEUROSCI.1544-06.2006
- Amphetamine withdrawal alters bistable states and cellular coupling in rat prefrontal cortex and nucleus accumbens neurons recorded in vivo.J. Neurosci. 2000; 20: 2332-2345https://doi.org/10.1523/JNEUROSCI.20-06-02332.2000
- Underlying mechanisms of impulse control disorders and dopamine agonist withdrawal syndrome in Parkinson's disease.J. Neurol. Disord. Strok. 2014; 2: 1-4
- Functional implications of dopa-mine D1 vs. D2 receptors: a ‘prepare and select’ model of the striatal direct vs. indirect pathways.Neuroscience. 2014; 282: 156-175https://doi.org/10.1016/j.neuroscience.2014.07.021
- Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: studies combining in vivo intracellular recordings and reverse microdialysis.J. Neurosci. 2002; 22: 294-304
- Increased striatal dopamine release in Parkinsonian patients with pathologicalgambling: a [11C] raclopride PET study.Brain. 2009; 132: 1376-1385https://doi.org/10.1093/brain/awp054
- Discounting of various types of rewards by women with and without binge eating disorder: evidence for general rather than specific differences.Psychol. Rec. 2011; 61: 561-582
- Monetary reward processing in obese individuals with and without binge eating disorder.Biol. Psychiatry. 2013; 73 (10.1016%2Fj.biopsych.2013.01.014): 877-886
- Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia.Neurology. 2007; 69: 1424-1433https://doi.org/10.1212/01.wnl.0000277461.06713.23
- Association of haplotypicvariants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.Hum. Mol. Genet. 2007; 16: 2844-2853https://doi.org/10.1093/hmg/ddm240
- Pathological gambling is linked to reduced activation of the mesolimbic reward system.Nat. Neurosci. 2005; 8: 147-148
- Dopamine and reward seeking: the role of ventral tegmental area.Rev. Neurosci. 2014; 25: 621-630
- Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study.J. Neurol. Neurosurg. Psychiatry. 2014; 85: 840-844
- Dopamine-relatedpersonality traits in Parkinson'sdisease.Neurol. 1993; 43: 505-508
- Novelty seeking and introversion do not predict the long-term risk of Parkinson disease.Neurol. 2010; 75: 349-357
- Personality, addiction, dopamine: insights from Parkinson's disease.Neuron. 2009; 61: 502-510https://doi.org/10.1016/j.neuron.2009.01.031
- Compulsive drug use linked to sensitized ventral striatal dopamine transmission.Ann. Neurol. 2006; 59: 852-858https://doi.org/10.1002/ana.20822
Article info
Publication history
Published online: January 22, 2019
Accepted:
January 21,
2019
Received in revised form:
December 29,
2018
Received:
September 29,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
