Highlights
- •The effectiveness of warfarin is dependent on the quality of anticoagulation control within the INR range of 2.0-3.0.
- •Despite the influence of genetic polymorphisms, the current guidelines do not consider these in all warfarin users.
- •We evaluated a total of 14,831 patients with warfarin medications.
- •In moderate/well-controlled TTR, a lower maintenance dose of warfarin (MDW) was significantly related to vascular events.
- •We propose that patients with a very low MDW might be alternatively considered for NOACs rather than warfarin.
Abstract
Background
The quality of anticoagulation is closely associated with efficacy and safety in warfarin
users. Although genetic polymorphisms have been related to warfarin dosages and vascular
events(VE), genetic evaluations have not been recommended for all warfarin users.
The aim is to evaluate the significance of the maintenance dose of warfarin (MDW)
on VE, considering the time in therapeutic range (TTR).
Methods
This retrospective study analyzed the data of patients who received warfarin for any
reasons. A total of 11,835 patients with warfarin were divided into quartiles by MDW.
We assessed TTR using the Rosendaal method and VE.
Results
VE occurred in 9.1% of the warfarin users. The mean TTR level was 34.0 ± 25.7%, and
the MDW was 3.38 ± 1.06 mg per day. Patients with VE were more likely to have a lower
MDW and lower TTR levels. In moderate- or well-controlled TTR status, a lower MDW
was significantly related to under-controlled anticoagulation and associated with
higher risks of VE. Lower MDW had a higher risk of stroke or arterial/venous thromboembolism
(Q1: OR, 1.57; 95% CI 1.25 to 1.96; Q2: OR, 1.40; 95% CI 1.12 to 1.75; Q3: OR, 1.35;
95% CI 1.08 to 1.68).
Conclusions
We suggest that patients with very low MDW might be at risk when using warfarin. Therefore,
we propose that patients with a very low MDW might be alternatively considered for
novel oral anticoagulants rather than warfarin.
Keywords
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Article info
Publication history
Published online: January 18, 2019
Accepted:
January 17,
2019
Received in revised form:
December 29,
2018
Received:
November 11,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
