Current hypotheses suggest that neuroinflammation and the immune system play a complex
role, either protective or toxic, in ALS pathogenesis [
1
,
2
,
3
]. In particular, compelling evidence indicate that increased blood level of natural
killer (NK) and NK-T cells may contribute to the disease development and progression
[
[2]
,
[3]
].Keywords
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References
- Protective and toxic neuroinflammation in amyotrophic lateral sclerosis.Neurotherapeutics. 2015; 12: 364-375
- Alteration of T cell subsets in ALS: a systemic immune activation?.Acta Neurol. Scand. 2012; 125: 260-264
- Correlation of peripheral immunity with rapid amyotrophic lateral sclerosis progression.JAMA Neurol. 2017; 74: 1446-1454
- Progression rate of ALSFRS-R at the time of diagnosis predicts survival time in ALS.Neurology. 2006; 66: 265-267
- Lymphoma, motor neuron diseases, and amyotrophic lateral sclerosis.Ann. Neurol. 1991; 29: 78-86
- Motor neuron syndromes in cancer patients.Ann. Neurol. 1997; 41: 722-730
- Paraneoplastic motor neuron disease associated with breast cancer.Eur. J. Neurol. 2014; 21: e5-e6
- Abnormal changes in NKT cells, the IGF-1 axis, and liver pathology in an animal model of ALS.PLoS ONE. 2011; 6e22374
Article info
Publication history
Published online: January 16, 2019
Accepted:
January 15,
2019
Received in revised form:
January 7,
2019
Received:
December 17,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
