Neuromyelitis optica spectrum disorders (NMOSD) is currently recognised as an inflammatory
central nervous system (CNS) disorder that most frequently involves the spinal cord
and optic nerve. Many studies have provided sufficient evidence for the importance
of the AQP4 antibody in the pathogenesis of NMOSD [
[1]
,
[2]
]. In addition, other autoantibodies such as the AQP-1 and myelin oligodendrocyte
glycoprotein (MOG) antibodies have also been found in NMOSD patients and have significant
effects in the immune process of the disease [
[3]
]. Neurofascin-155 (NF155) is a protein expressed in both CNS and peripheral nervous
system (PNS) myelin sheath. Studies have shown that the NF155 antibody plays an important
role in chronic inflammatory demyelinating polyradiculopathy (CIDP) and combined central
and peripheral demyelination disease [
[4]
,
[5]
]. In contrast, there have so far been no previous reports of concurrent NF155 and
AQP4 antibody involvement in NMOSD. We herein present the cases of two patients with
seropositive NMOSD, who carried of the NF155 antibody, which are mainly IgG1 and IgG2
subclasses.Keywords
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Article info
Publication history
Published online: January 16, 2019
Accepted:
January 15,
2019
Received in revised form:
January 11,
2019
Received:
November 12,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
