Highlights
- •CSO-PVS was observed in 94% of healthy elderly individuals without deep WMH.
- •Conversely, elderlies with invisible or sparse CSO-PVS had high grade of deep WMH.
- •Elderlies with deep WMH had significantly fewer MRI-visible CSO-PVS.
- •Elderlies with visible BG-PV had high grade of deep WMH and periventricular WMH.
- •CSO-PVS looks different from BG-PVS in the relationship with deep WMH.
Abstract
Purpose
Brain interstitial fluid plays an important role in the excretion of metabolic waste
products into the cerebrospinal fluid through perivascular spaces (PVS). To investigate
the normal function of PVS in healthy elderly individuals, we assessed the relationship
between PVS and white matter hyperintensity (WMH) on MRI in two locations.
Methods
This study included 296 healthy individuals aged ≥60 years without a history of brain
disease who underwent brain MRI. The severities of PVS and WMH were assessed on the
location-specific classification in the basal ganglia (BG-PVS) or centrum semiovale
(CSO-PVS), and in the deep or periventricular WMH.
Results
The severity of BG-PVS was significantly associated with the severities of deep and
periventricular WMHs. In contrast, the severity of CSO-PVS was inversely associated
with the severity of deep WMH and was not significantly associated with that of periventricular
WMH. The multivariate odds ratios of severe deep WMH for BG-PVS and CSO-PVS were 1.18
(95% CIs: 1.01–1.38) and 0.68 (0.54–0.86), respectively, compared with none deep WMH.
Conclusions
CSO-PVS looks different from BG-PVS in their relationship with deep WMHs. Therefore,
CSO-PVS might play an essential role in the normal interstitial fluid drainage system,
not as a biomarker of arteriosclerosis.
Graphical abstract
Graphical Abstract
Keywords
Abbreviations:
BG (basal ganglia), CSO (centrum semiovale), DBP (diastolic blood pressure), eGFR (estimated glomerular filtration rate), FLAIR (fluid-attenuated inversion recovery), MRI (magnetic resonance imaging), PVS (perivascular space), SBP (systolic blood pressure), SD (standard deviation), T (tesla), WMH (white matter hyperintensity)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: January 16, 2019
Accepted:
January 14,
2019
Received in revised form:
December 11,
2018
Received:
September 19,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
