- •The prevalence of PD in Israel was found to be 0.5% in the general population.
- •The Mantel-Haenszel (M-H) odds ratio of PD for hepatitis C virus positive patients was 1.18.
- •The M-H OR of PD for patients diagnosed with nonalcoholic steatohepatitis was 1.13.
- •Co infection of HCV and HBV was not associated with an increased risk for PD.
To study the association between hepatitis C and B viruses and Parkinson's disease (PD) in Israel.
A retrospective cohort study was performed by analyzing the computerized database of Clalit Healthcare Service in Israel. Cohorts of people with hepatitis C virus (HCV) infection, hepatitis B virus (HBV) infection and nonalcoholic steatohepatitis (NASH) were constructed and compared to a reference cohort for prevalence of PD.
The prevalence of PD in Israel was found to be 0.5% in the general population. The M-H (Mantel-Haenszel) odds ratio (OR) of PD for HBV-positive patients was 1.08 (95% CI: 1.00–1.16). The M-H OR of PD for HCV-positive patients was 1.18 (95% CI: 1.04–1.35). The M-H OR of PD for patients infected with both hepatitis C and B was 1.13 (95% CI: 0.87–1.47). The M-H OR of PD for patients diagnosed with nonalcoholic steatohepatitis (NASH) was 1.13 (95% CI: 1.08–1.19).
We report evidence supporting a minor increased risk for PD in patients with HCV. Co infection of HCV and HBV was not associated with an increased risk for PD. The increased risk for PD in the group of patients with NASH, raises the possibility that liver disease per se is a risk factor for PD rather than viral infection. In addition, it cannot be ruled out that the association is, at least in part, the result of the occurrence of cirrhosis induced parkinsonism that was misclassified as PD.
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- Epidemiology of Parkinson disease.Neurol. Clin. 2016; 34: 955-965
- Prevalence of parkinson's disease across North America.NPJ. Parkinson's Dis. 2018; 4: 1-7
- Parkinson disease.Nat. Rev. Dis. Prim. 2017; 317013
- Hepatitis C virus infection: a risk factor for Parkinson's disease.J. Viral Hepat. 2015; 22: 784-791
- Prevalence and significance of neurocognitive dysfunction in hepatitis C in the absence of correlated risk factors.Hepatology. 2005; 41: 801-808
- Emerging evidence of hepatitis C virus neuroinvasion.AIDS. 2005; 19: S144
- Hepatitis C virus and the brain.J. Viral Hepat. 2012; 19: 301-306
- Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment.Gut. 2006; 55: 1624-1630
- Self-Propagation of Pathogenic Protein Aggregates in Neurodegenerative Diseases.Nature. 2013; 501: 45-51
- Transmission of neurodegenerative disorders through blood transfusion: a cohort study.Ann. Intern. Med. 2016; 165: 316
- Chronic hepatitis B virus infection.Lancet. 2018; 392: 2313-2324
- Contribution of quantitative viral markers to document hepatitis B virus compartmentalization in cerebrospinal fluid during hepatitis B with neuropathies.J. NeuroVirol. 2018; 24: 769-772
- Hepatitis C virus infection as a risk factor for parkinson disease: a nationwide cohort study.Neurology. 2016; 86: 840-846
- Viral hepatitis and parkinson disease: a national record-linkage study.Neurology. 2017; 88: 1630-1633
- Hepatitis C virus infection and risk of Parkinson's disease: a systematic review and meta-analysis.Eur. J. Gastroenterol. Hepatol. 2018; 30: 9-13
- Non-alcoholic fatty liver disease: controlling an emerging epidemic, challenges, and future directions.Ann. Gastroenterol. 2018; 31: 288
- Genetic movement disorders in patients of Jewish ancestry.JAMA Neurol. 2014; 71: 1567-1572
- Parkinsonism in cirrhosis: pathogenesis and current therapeutic options.Metab. Brain Dis. 2013; 28: 261-267
- Acquired hepatocerebral degeneration: clinical characteristics and MRI findings.Eur. J. Neurol. 2010; 17: 1463-1470
- Acquired hepatocerebral degeneration.J. Neurol. 2009; 256: 320-332
Published online: January 11, 2019
Accepted: January 10, 2019
Received in revised form: January 4, 2019
Received: December 3, 2018
© 2019 Published by Elsevier B.V.