Letter to the Editor| Volume 398, P2-3, March 15, 2019

Auditory brainstem response analysis for long-term central auditory function sequelae in patients with chronic arsenic intoxication: A cross-sectional study

Published:January 09, 2019DOI:


      • The long-term auditory sequelae after arsenic exposure have never been evaluated.
      • We evaluated these sequelae in chronically-exposed and control groups.
      • The results of ABR analysis were similar between the groups.
      • The exposed group had normal hearing function 40 years after exposure cessation.



      ABR (auditory brainstem response), SEP (somatosensory evoked potential), VEP (visual evoked potential)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Abdul K.S.
        • Jayasinghe S.S.
        • Chandana E.P.
        • Jayasumana C.
        • De Silva P.M.
        Arsenic and human health effects: a review.
        Environ. Toxicol. Pharmacol. 2015; 40: 828-846
        • Mochizuki H.
        • Yagi K.
        • Tsuruta K.
        • Taniguchi A.
        • Ishii N.
        • Shiomi K.
        • Nakazato M.
        Prolonged central sensory conduction time in patients with chronic arsenic exposure.
        J. Neurol. Sci. 2016; 361: 39-42
        • Sinczuk-Walczak H.
        • Szymczak M.
        • Halatek T.
        Effects of occupational exposure to arsenic on the nervous system: clinical and neurophysiological studies.
        Int. J. Occup. Med. Environ. Health. 2010; 23: 347-355
        • Kesici G.G.
        Arsenic ototoxicity.
        J. Otol. 2016; 11: 13-17
        • Supapong S.
        • Sriratanabun J.
        Brainstem auditory evoked potentials (BAEPs) study in chronic arsenic poisoning patients.
        J. Med. Assoc. Thail. 2005; 88: S226-S230
        • Ishii N.
        • Mochizuki H.
        • Ebihara Y.
        • Shiomi K.
        • Nakazato M.
        Clinical symptoms, neurological signs, and electrophysiological findings in surviving residents with probable arsenic exposure in Toroku, Japan.
        Arch. Environ. Contam. Toxicol. 2018; 75: 521-529
        • Anniko M.
        Atoxyl-induced damage to the sensory cells in the organ of Corti in the Guinea pig cochlea.
        Virchows Arch. B Cell Pathol. 1976; 21: 267-277
        • Saunders J.E.
        • Jastrzembski B.G.
        • Buckey J.C.
        • Enriquez D.
        • MacKenzie T.A.
        • Karagas M.R.
        Hearing loss and heavy metal toxicity in a Nicaraguan mining community: audiological results and case reports.
        Audiol. Neurootol. 2013; 18: 101-113
        • Bencko V.
        • Symon K.
        Test of environmental exposure to arsenic and hearing changes in exposed children.
        Environ. Health Perspect. 1977; 19: 95-101
        • Francois M.
        • Dehan E.
        • Carlevan M.
        • Dumont H.
        Use of auditory steady-state responses in children and comparison with other electrophysiological and behavioral tests.
        Eur. Ann. Otorhinolaryngol. Head Neck Dis. 2016; 133: 331-335