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Letter to the Editor| Volume 395, P88-90, December 15, 2018

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Crossed cerebellar diaschisis in Creutzfeldt-Jakob disease evaluated through single photon emission computed tomography

Published:September 24, 2018DOI:https://doi.org/10.1016/j.jns.2018.09.027

      Abstract

      Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of human prion disease; it is characterized as a transmissible spongiform encephalopathy. Previously, only two case reports have discussed crossed cerebellar diaschisis (CCD) and sCJD. Herein, we detected CCD in five patients with sCJD and four patients with genetic CJD through SPECT. The combined data of the nine patients further supported CCD when analyzed by 3D-SSP. CCD can occur in several disorders, including, stroke, epilepsy, and encephalitis. Hence, CCD possibly could help in making earlier CJD diagnoses. Further studies with more patients are necessary to confirm the strong relationship here suggested between CJD and CCD.

      Abbreviations:

      CJD (Creutzfeldt Jakob disease), ELISA (enzyme-linked immunosorbent assay), RT-QUIC (real-time quaking-induced conversion), PSWCs (periodic sharp wave complexes), EEG (electroencephalogram), PRNP (prion protein), N.A. (not assessed), gCJD (genetic CJD)

      Keywords

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      References

        • Zerr I.
        • Kallenberg K.
        • Summers D.M.
        • Romero C.
        • Taratuto A.
        • Heinemann U.
        • Breithaupt M.
        • Varges D.
        • Meissner B.
        • Ladogana A.
        • Schuur M.
        • Haik S.
        • Collins S.J.
        • Jansen G.H.
        • Stokin G.B.
        • Pimentel J.
        • Hewer E.
        • Collie D.
        • Smith P.
        • Roberts H.
        • Brandel J.P.
        • van Duijn C.
        • Pocchiari M.
        • Begue C.
        • Cras P.
        • Will R.G.
        • Sanchez-Juan P.
        Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease.
        Brain. 2009; 132 (Pt 10): 2659-2668
        • Wiesendanger M.
        Constantin von Monakow (1853-1930): a pioneer in interdisciplinary brain research and a humanist.
        Comptes rendus biologies. 2006; 329: 406-418
        • Sommer W.H.
        • Bollwein C.
        • Thierfelder K.M.
        • Baumann A.
        • Janssen H.
        • Ertl-Wagner B.
        • Reiser M.F.
        • Plate A.
        • Straube A.
        • von Baumgarten L.
        Crossed cerebellar diaschisis in patients with acute middle cerebral artery infarction: Occurrence and perfusion characteristics.
        J. Cereb. Blood Flow Metab. 2016; 36: 743-754
        • Mahale R.
        • Mehta A.
        • Rangasetty S.
        Crossed Cerebellar Diaschisis due to Rasmussen Encephalitis.
        Pediatr. Neurol. 2015; 53: 272-273
        • Teoh E.J.
        • Green A.L.
        • Bradley K.M.
        Crossed cerebellar diaschisis due to cerebral diffuse large B cell lymphoma on 18F-FDG PET/CT.
        Int. J. Hematol. 2014; 100: 415-416
        • Kastenbauer S.
        • Schulz-Schaeffer W.J.
        • Tatsch K.
        • Yousry T.A.
        • Kretzschmar H.A.
        • Pfister H.W.
        Crossed cerebellar diaschisis: a clue to the mechanism of ataxic hemiparesis in Creutzfeldt-Jakob disease?.
        J. Neurol. 2001; 248: 1093-1095
        • Wile D.
        • Dhaliwal H.
        • Sarna J.R.
        • Molnar C.P.
        • Scott J.N.
        • Costello F.
        • Furtado S.
        • Joseph J.T.
        Diaschisis as the presenting feature in sporadic Creutzfeldt-Jakob disease.
        JAMA neurology. 2013; 70: 408-409
        • Atarashi R.
        • Satoh K.
        • Sano K.
        • Fuse T.
        • Yamaguchi N.
        • Ishibashi D.
        • Matsubara T.
        • Nakagaki T.
        • Yamanaka H.
        • Shirabe S.
        • Yamada M.
        • Mizusawa H.
        • Kitamoto T.
        • Klug G.
        • McGlade A.
        • Collins S.J.
        • Nishida N.
        Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.
        Nat. Med. 2011; 17: 175-178
        • Nishioka K.
        • Hayashi T.
        • Suzuki M.
        • Li Y.
        • Nakayama S.
        • Matsushima T.
        • Usui C.
        • Shibata N.
        • Motoi Y.
        • Tanaka R.
        • Nishioka K.
        • Hattori N.
        Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series.
        Int. J. Rheum. Dis. 2016; 19: 21-29
        • Forster A.
        • Kerl H.U.
        • Goerlitz J.
        • Wenz H.
        • Groden C.
        Crossed cerebellar diaschisis in acute isolated thalamic infarction detected by dynamic susceptibility contrast perfusion MRI.
        PLoS One. 2014; 9e88044