Abstract
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of human prion disease;
it is characterized as a transmissible spongiform encephalopathy. Previously, only
two case reports have discussed crossed cerebellar diaschisis (CCD) and sCJD. Herein,
we detected CCD in five patients with sCJD and four patients with genetic CJD through
SPECT. The combined data of the nine patients further supported CCD when analyzed
by 3D-SSP. CCD can occur in several disorders, including, stroke, epilepsy, and encephalitis.
Hence, CCD possibly could help in making earlier CJD diagnoses. Further studies with
more patients are necessary to confirm the strong relationship here suggested between
CJD and CCD.
Abbreviations:
CJD (Creutzfeldt Jakob disease), ELISA (enzyme-linked immunosorbent assay), RT-QUIC (real-time quaking-induced conversion), PSWCs (periodic sharp wave complexes), EEG (electroencephalogram), PRNP (prion protein), N.A. (not assessed), gCJD (genetic CJD)Keywords
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Article info
Publication history
Published online: September 24, 2018
Accepted:
September 21,
2018
Received in revised form:
September 20,
2018
Received:
July 30,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
