Letter to the Editor| Volume 395, P25-28, December 15, 2018

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Adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia mimicking systemic lupus erythematosus cerebral vasculitis

Published:September 22, 2018DOI:


      • Consider a leukodystrophy in patients with a ‘refractory’ cerebral vasculitis
      • CSF1R mutation analysis and a brain biopsy are often required to exclude mimics
      • ALSP may present with early onset dementia and personality changes
      • A progressive motor and gait disturbance is often seen, occasionally with seizures


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