Clinical Short Communication| Volume 388, P128-132, May 15, 2018

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Predictors of cognitive impairment in multiple system atrophy

Published:March 10, 2018DOI:


      • We investigated clinical and radiological findings in MSA patients.
      • MMSE score correlates with disease duration, global disability, and dysautonomia.
      • FAB score correlates with motor function and cerebral white matter lesions.
      • Residual urine volume correlates with rapidly progressive cognitive impairment.



      To determine predictors of cognitive impairment and frontal dysfunction in patients with multiple system atrophy (MSA).


      We recruited 59 patients with MSA and determined the predictors of a decline in the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB) scores.


      The MMSE scores negatively correlated with disease duration, Unified MSA Rating Scale (UMSARS) part 1 and 4 scores, and residual urine volume, and positively correlated with the coefficient of variation of electrocardiographic RR intervals. The FAB scores negatively correlated with the UMSARS part 2 score, periventricular hyperintensity grade, and deep white matter hyperintense signal grade. A significant predictor of rapidly progressive cognitive impairment was a high residual urine volume.


      Impairment of global cognitive function correlates with the long-term disease duration, global disability due to the disease, and autonomic dysfunction, whereas frontal dysfunction correlates with motor function and degeneration of cerebral white matter.


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