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Tardive syndromes

Published:February 05, 2018DOI:https://doi.org/10.1016/j.jns.2018.02.005

      Abstract

      Tardive syndromes are a group of hyperkinetic and hypokinetic movement disorders that occur after some delay following exposure to dopamine receptor blocking agents such as antipsychotic and anti-emetic drugs. The severity of these disorders ranges from mild to disabling or even life-threatening. There is a wide range of recognized tardive phenomenologies that may occur in isolation or in combination with each other. These phenomenologies include stereotypy, dystonia, chorea, akathisia, myoclonus, tremor, tics, gait disorders, parkinsonism, ocular deviations, respiratory dyskinesia, and a variety of sensory symptoms. Recognition of the various tardive phenomenologies may not only lead to early diagnosis but also to appropriate therapeutic intervention. This review focuses on the diagnosis and clinical course of tardive syndromes and how to distinguish between the various phenomenologies as well as how to differentiate them from other, similar but etiologically different, movement disorders.

      Keywords

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      References

        • Frei K.
        • Truong D.
        • Fahn S.
        • Jankovic J.
        • Hauser Robert A.
        The nosology of tardive syndromes.
        J. Neurol. Sci. 2018; ([In this issue])https://doi.org/10.1016/j.jns.2018.02.008
        • Faurbye A.
        • Rasch P.J.
        • Petersen P.B.
        • Brandborg G.
        • Pakkenberg H.
        Neurological symptoms in pharmacotherapy of psychoses.
        Acta Psychiatr. Scand. 1964; 40: 10-27
        • Morrens M.
        • Hulstijn W.
        • Lewi P.J.
        • De Hert M.
        • Sabbe B.G.C.
        Stereotypy in schizophrenia.
        Schizophr. Res. 2006; 84: 397-404
        • Fahn S.
        • Jankovic J.
        • Hallett M.
        Principles and Practice of Movement Disorders.
        2nd ed. 2011 (380-8 pp.)
        • Wijemanne S.
        • Jankovic J.
        Movement disorders in catatonia.
        J. Neurol. Neurosurg. Psychiatry. 2015; 86: 825-832
        • American Psychiatric Association
        Medication-induced movement disorders and other adverse effects of medication.
        in: Diagnostic and Statistical Manual of Mental Disorders. fifth edition. American Psychiatric Association, 2013
        • Fahn S.
        • Jankovic J.
        • Hallett M.
        Principles and Practice of Movement Disorders.
        2nd ed. 2011: 415-446
        • Barow E.
        • Schneider S.A.
        • Bhatia K.P.
        • Ganos C.
        Oculogyric crises: etiology, pathophysiology and therapeutic approaches.
        Parkinsonism Relat. Disord. 2017; 36: 3-9
        • Burkhard P.R.
        Acute and subacute drug-induced movement disorders.
        Parkinsonism Relat. Disord. 2014; 20: S108-12
        • Lohr J.B.
        • Eidt C.A.
        • Abdulrazzaq Alfaraj A.
        • Soliman M.A.
        The clinical challenges of akathisia.
        CNS Spectr. 2015; 20: 1-14
        • Waln O.
        • Jankovic J.
        An update on tardive dyskinesia: from phenomenology to treatment.
        Tremor Other Hyperkinet Mov. 2013; 3: 1-11
        • Vijayakumar D.
        • Jankovic J.
        Drug-induced dyskinesia, part 2: treatment of tardive dyskinesia.
        Drugs. 2016; 76: 779-787
        • Raharaj S.K.
        • Kongasseri S.
        • Behere R.V.
        • Sharma P.S.
        Mirtazapine for antipsychotic-induced acute akathisia: a systematic review and meta-analysis of randomized placebo-controlled trials.
        Ther. Adv. Psychopharmacol. 2015; 5: 307-313
        • Velamoor R.
        Neuroleptic malignant syndrome: a neuro-psychiatric emergency: recognition, prevention, and management.
        Asian J. Psychiatr. 2017; 29: 106-109
        • Ware M.R.
        • Feller D.B.
        • Hall K.L.
        Neuroleptic malignant syndrome: diagnosis and management.
        Prim Care Companion CNS Disord. 2018; 20
        • Strassnig M.
        • Rosenfeld A.
        • Harvey P.D.
        Tardive Dyskinesia: Motor System Impairments, Cognition and Everyday Functioning.
        2017: 1-8
        • Mailman R.B.
        • Murthy V.
        Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?.
        Curr. Pharm. Des. 2010; 16: 488-501
        • Frankel J.S.
        • Schwartz T.L.
        Brexpiprazole and cariprazine: distinguishing two new atypical antipsychotics from the original dopamine stabilizer aripiprazole.
        Ther. Adv. Psychopharmacol. 2017; 7: 29-41
        • Farah A.
        Atypicality of atypical antipsychotics.
        Prim Care Companion J. Clin. Psychiatry. 2005; 7: 268-274
        • Wijemanne S.
        • Jankovic J.
        • Evans R.W.
        Movement disorders from the use of metoclopramide and other antiemetics in the treatment of migraine.
        Headache. 2016; 56: 153-161
        • Kenney C.
        • Hunter C.
        • Davidson A.
        • Jankovic J.
        Metoclopramide, an increasingly recognized cause of tardive dyskinesia.
        J. Clin. Pharmacol. 2008; 48: 379-384
        • Pasricha P.J.
        • Pehlivanov N.
        • Sugumar A.
        • Jankovic J.
        Drug insight: from disturbed motility to disordered movement—a review of the clinical benefits and medicolegal risks of metoclopramide.
        Nat. Clin. Pract. Gastroenterol. Hepatol. 2006; 3: 138-148
        • Jankovic J.
        Dopamine depleters in the treatment of hyperkinetic movement disorders.
        Expert. Opin. Pharmacother. 2016; 17: 2461-2470
        • Cornett E.M.
        • Novitch M.
        • Kaye A.D.
        • Kata V.
        • Kaye A.M.
        Medication-induced tardive dyskinesia: a review and update.
        . 2017; 17: 162-174
        • Lerner P.P.
        • Miodownik C.
        • Lerner V.
        Tardive dyskinesia (syndrome): current concept and modern approaches to its management.
        Psychiatry Clin. Neurosci. 2015; 69: 321-334
        • Lehman A.F.
        • Lieberman J.A.
        • Dixon L.B.
        • McGlashan T.H.
        • Miller A.L.
        • Perkins D.O.
        • et al.
        American psychiatric association, steering committee on practice guidelines, practice guideline for the treatment of patients with schizophrenia, second edition.
        Am. J. Psychiatry. 2004; 161: 1-56
        • Kim J.
        • MacMaster E.
        • Schwartz T.L.
        Tardive dyskinesia in patients treated with atypical antipsychotics: case series and brief review of etiologic and treatment considerations.
        Drugs Context. 2014; 3: 1-10
        • Carbon M.
        • Hsieh C.H.
        • Kane J.M.
        • Correll C.U.
        Tardive dyskinesia prevalence in the period of second-generation antipsychotic use: a meta-analysis.
        J. Clin. Psychiatry. 2017; 78: e264-e278
        • Peña M.S.
        • Yaltho T.C.
        • Jankovic J.
        Tardive dyskinesia and other movement disorders secondary to aripiprazole.
        Mov. Disord. 2011; 26: 147-152
        • Goyal R.
        • Devi S.H.
        A case of aripiprazole induced tardive dyskinesia in a neuroleptic-naïve patient with two years of follow up.
        Clin. Psychopharmacol. Neurosci. 2014; 12: 69-71
        • Patra S.
        Tardive dyskinesia and covert dyskinesia with aripiprazole: a case series.
        . 2016; 11: 102-103
        • Heitzmann E.
        • Javelot H.
        • Weiner L.
        • Michel B.
        C. Description, Case Report A Case of Aripiprazole-induced Tardive Dyskinesia With Dramatic Evolution.
        2016
        • Bhidayasiri R.
        • Boonyawairoj S.
        Spectrum of tardive syndromes: clinical recognition and management.
        Postgrad. Med. J. 2011; 87: 132-141
        • Vinuela A.
        • Kang U.J.
        Reversibility of tardive dyskinesia syndrome.
        Tremor Other Hyperkinet Mov. 2014; 4: 282
        • Zutshi D.
        • Cloud L.J.
        • Factor S.A.
        Tardive syndromes are rarely reversible after discontinuing dopamine receptor blocking agents: experience from a university-based movement disorder clinic.
        Tremor Other Hyperkinetic Mov. 2014; 4: 1-9
        • Kiriakakis V.
        • Bhatia K.P.
        • Quinn N.P.
        • Marsden C.D.
        The natural history of tardive dystonia. A long-term follow-up study of 107 cases.
        Brain. 1998; 121: 2053-2066
        • Glazer W.M.
        • Morgenstern H.
        • Schooler N.
        • Berkman C.S.
        • Moore D.C.
        Predictors of improvement in tardive dyskinesia following discontinuation of neuroleptic medication.
        Br. J. Psychiatry. 1990; 157: 585-592
        • Teo J.T.
        • Edwards M.J.
        • Bhatia K.
        Tardive dyskinesia is caused by maladaptive synaptic plasticity: a hypothesis.
        Mov. Disord. 2012; 27: 1205-1215
        • Schooler N.R.
        • Kane J.M.
        Research diagnoses for tardive dyskinesia.
        Arch. Gen. Psychiatry. 1982; 39: 486-487
        • Gardos G.
        • Cole J.O.
        • Tarsy D.
        Withdrawal syndromes associated with antipsychotic drugs.
        Am. J. Psychiatry. 1978; 135: 1321-1324
        • A.P.A.
        Practice guideline for the treatment of patients with bipolar disorder.
        Am. J. Psychiatry. 1994; 151: 1-36
        • Bark N.
        • Florida D.
        • Gera N.
        • Varardi R.
        • Harghel L.
        • Adlington K.
        Evaluation of the routine clinical use of the brief psychiatric rating scale (BPRS) and the abnormal involuntary movement scale (AIMS).
        J. Psychiatr. Pract. 2011; 17: 300-303
        • Guy W.
        ECDEU Assessment Manual for Psychopharmacology: Revised.
        1976: 534-537
        • Fahn S.
        Neural mechanisms in disorders of movement.
        in: Crossman A. Sambrook M.A. Neural Mechanism in Disorders of Movement. 1989 (249–267 pp.)
        • Stacy M.
        • Cardoso F.
        • Jankovic J.
        Tardive stereotypy and other movement disorders in tardive dyskinesias.
        Neurology. 1993; 43: 937-941
        • Blanchet P.J.
        • Popovici R.
        • Guitard F.
        • Rompré P.H.
        • Lamarche C.
        • Lavigne G.J.
        Pain and denture condition in edentulous orodyskinesia: comparisons with tardive dyskinesia and control subjects.
        Mov. Disord. 2008; 23: 1837-1842
        • Jung H.H.
        • Danek A.
        • Walker R.H.
        Neuroacanthocytosis syndromes.
        Orphanet J. Rare Dis. 2011; 6: 68
        • Jankovic J.
        Tardive syndromes and other drug-induced movement disorders.
        Clin. Neuropharmacol. 1995; 18: 197-214
        • Fekete R.
        • Jankovic J.
        Upper facial chorea in Huntington disease.
        J. Clin. Mov. Disord. 2014; 1: 7
        • Lumetti S.
        • Ghiacci G.
        • Macaluso G.M.
        • Amore M.
        • Galli C.
        • Calciolari E.
        • et al.
        Tardive dyskinesia, oral parafunction, and implant-supported rehabilitation.
        Case Rep. Dent. 2016; (Epub 2016 Dec 6)
        • Kaneko K.
        • Yuasa T.
        • Miyatake T.
        • Tsuji S.
        Stereotyped hand clasping: an unusual tardive movement disorder.
        Mov. Disord. 1993; 8: 230-231
        • Yassa R.
        • Lal S.
        Respiratory irregularity and tardive dyskinesia. A prevalence study.
        Acta Psychiatr. Scand. 1986; 73: 506-510
        • Wilcox P.G.
        • Bassett A.
        • Jones B.
        • Fleetham J.A.
        Respiratory dysrhythmias in patients with tardive dyskinesia.
        Chest. 1994; 105: 203-207
        • Horiguchi J.
        • Shingu T.
        • Hayashi T.
        • Kagaya A.
        • Yamawaki S.
        • Horikawa Y.
        • Kitadai Y.
        • Inoue M.
        • Nishikawa T.
        Antipsychotic-induced life-threatening “esophageal dyskinesia”.
        Int. Clin. Psychopharmacol. 1999; 14: 123-127
        • Ure R.J.
        • Dhanju S.
        • Lang A.E.
        • Fasano A.
        Unusual tremor syndromes: know in order to recognise.
        J. Neurol. Neurosurg. Psychiatry. 2016; 87: 1191-1203
        • Liang C.S.
        • Yang F.W.
        • Huang Y.C.
        Rabbit syndrome following discontinuation of paliperidone in a patient with schizoaffective disorder.
        J. Clin. Psychopharmacol. 2012; 32: 720-721
        • Sansare K.
        • Singh D.
        • Khanna V.
        • Karjodkar F.R.
        Risperidone-induced rabbit syndrome: an unusual movement disorder.
        N. Y. State Dent. J. 2012; 78 (78): 44-46
        • Druckman R.
        • Seelinger D.
        • Thulin B.
        Chronic involuntary movements induced by phenothiazines.
        J. Nerv. Ment. Dis. 1962; 135: 69-76
        • Burke R.E.
        • Fahn S.
        • Jankovic J.
        • Marsden C.D.
        • Lang A.E.
        • Gollomp S.
        • et al.
        Tardive dystonia: late-onset and persistent dystonia caused by antipsychotic drugs.
        Neurology. 1982; 32: 1335-1346
        • Kang U.J.
        • Burke R.E.
        • Fahn S.
        Natural history and treatment of tardive dystonia.
        Mov. Disord. 1986; 1: 193-208
        • Wojcik J.D.
        • Falk W.E.
        • Fink J.S.
        • Cole J.O.
        • Gelenberg A.J.
        A review of 32 cases of tardive dystonia.
        Am. J. Psychiatry. 1991; 148: 1055-1059
        • van Harten P.N.
        • Matroos G.E.
        • Van Os J.
        The course of tardive dystonia in Afro Caribbean patients, a population-based study: the Curacao extrapyramidal syndromes study: VII.
        Schizophr. Res. 2008; 98: 79-83
        • Konrad C.
        • Vollmer-Haase J.
        • Gaubitz M.
        • Nabavi D.G.
        • Reilmann R.
        • Knecht S.
        Fracture of the odontoid process complicating tardive dystonia.
        Mov. Disord. 2004; 19: 983-985
        • Tan E.K.
        • Jankovic J.
        Tardive and idiopathic oromandibular dystonia: a clinical comparison.
        J. Neurol. Neurosurg. Psychiatry. 2000; 68: 186-190
        • Samie M.R.
        • Dannenhoffer M.A.
        • Rozek S.
        Life-threatening tardive dyskinesia caused by metoclopramide.
        Mov. Disord. 1987; 2: 125-129
        • Hayashi T.
        • Nishikawa T.
        • Koga I.
        • Uchida Y.
        • Yamawaki S.
        Life-threatening dysphagia following prolonged neuroleptic therapy.
        Clin. Neuropharmacol. 1997; 20: 77-81
        • van Harten P.N.
        • Hoek H.W.
        • Matroos G.E.
        • Koeter M.
        • Kahn R.S.
        The inter-relationships of tardive dyskinesia, parkinsonism, akathisia and tardive dystonia: the Curaçao extrapyramidal syndromes study II.
        Schizophr. Res. 1997; 26: 235-242
        • Gardos G.
        • Cole J.O.
        • Salomon M.
        • Schniebolk S.
        Clinical forms of severe tardive dyskinesia.
        Am. J. Psychiatry. 1987; 144: 895-902
        • Fountoulakis K.N.
        • Samara M.
        • Siapera M.
        • Iacovides A.
        Tardive Tourette-like syndrome.
        Int. Clin. Psychopharmacol. 2011; 26: 237-242
        • Braude W.M.
        • Barnes T.R.
        Late-onset akathisia-an indicant of covert dyskinesia: two case reports.
        Am. J. Psychiatry. 1983; 140: 611-612
        • Fahn S.
        Tardive dyskinesia may be only akathisia.
        N. Engl. J. Med. 1978; 299: 202-203
        • Weiner W.J.
        • Luby E.D.
        Persistent akathisia following neuroleptic withdrawal.
        Ann. Neurol. 1983; 13: 466-467
        • Munetz M.R.
        • Cornes C.L.
        Akathisia, pseudoakathisia and tardive dyskinesia: clinical examples.
        Compr. Psychiatry. 1982; 23: 345-352
        • Burke R.E.
        • Kang U.J.
        • Jankovic J.
        • Miller L.G.
        • Fahn S.
        Tardive akathisia: an analysis of clinical features and response to open therapeutic trials.
        Mov. Disord. 1989; 4: 157-175
        • Barnes T.R.
        • Braude W.M.
        Akathisia variants and tardive dyskinesia.
        Arch. Gen. Psychiatry. 1985; 42: 874-878
        • Aquino C.C.H.
        • Lang A.E.
        Tardive dyskinesia syndromes: current concepts.
        Parkinsonism Relat. Disord. 2014; 20: S113-S117
        • Jankovic J.
        Leg stereotypy disorder.
        J. Neurol. Neurosurg. Psychiatry. 2016 Feb; 87: 220-221
        • Lotia M.
        • York M.K.
        • Strutt A.M.
        • Jankovic J.
        Leg stereotypy syndrome: phenomenology and prevalence.
        J. Neurol. Neurosurg. Psychiatry. 2018; (in press, epub ahead of print)
        • Little J.T.
        • Jankovic J.
        Tardive myoclonus.
        Mov. Disord. 1987; 2: 307-311
        • Tominaga H.
        • Fukuzako H.
        • Izumi K.
        • Koja T.
        • Fukuda T.
        • Fujii H.
        • Matsumoto K.
        • Sonoda H.
        • Imamura K.
        Tardive myoclonus.
        Lancet. 1987; 329: 322
        • Fukuzako H.
        • Tominaga H.
        • Izumi K.
        • Koja T.
        • Nomoto M.
        • Hokazono Y.
        • Kamei K.
        • Fujii H.
        • Fukuda T.
        • Matsumoto K.
        Postural myoclonus associated with long-term administration of neuroleptics in schizophrenic patients.
        Biol. Psychiatry. 1990; 27: 1116-1126
        • Stacy M.
        • Jankovic J.
        Tardive tremor.
        Mov. Disord. 1992; 7: 53-57
        • Tarsy D.
        • Indorf G.
        Tardive tremor due to metoclopramide.
        Mov. Disord. 2002; 17: 620-621
        • Shprecher D.
        Sensory trick with metoclopramide-associated tardive tremor.
        BMJ Case Rep. 2012; 2012 (bcr1120115156-bcr1120115156)
        • Patel N.
        • Hanfelt J.
        • Marsh L.
        • Jankovic J.
        Alleviating manoeuvres (sensory tricks) in cervical dystonia.
        J. Neurol. Neurosurg. Psychiatry. 2014; 85: 882-884
        • Yogaratnam J.
        • Xu C.
        • Thinn D.S.S.
        • Yoong L.K.
        • Khoo C.L.
        • Sim K.
        De novo tardive Tourette-like syndrome after prolonged combination depot and oral neuroleptic therapy.
        Acta Neuropsychiatr. 2013; 25: 122-124
        • Black K.J.
        • Jankovic J.
        • Hershey T.
        • McNaught K.S.P.
        • Mink J.W.
        • Walkup J.
        Progress in research on Tourette syndrome.
        J. Obsessive Compuls. Relat. Disord. 2014; 3: 359-362
        • Cardoso F.
        Differential diagnosis of Huntington's disease: what the clinician should know.
        Neurodegener. Dis. Manag. 2014; 4: 67-72
        • Jankovic J.
        • Glass J.P.
        Metoclopramide-induced phantom dyskinesia.
        Neurology. 1985; 35: 432-435
        • Simpson G.M.
        • Shrivastava R.K.
        Abnormal gaits in tardive dyskinesia.
        Am. J. Psychiatry. 1978; 135: 865
        • Yassa R.
        Functional impairment in tardive dyskinesia: medical and psychosocial dimensions.
        Acta Psychiatr. Scand. 1989; 80: 64-67
        • Lauterbach E.C.
        • Singh H.
        • Simpson G.M.
        • Morrison R.L.
        Gait disorders in tardive dyskinesia.
        Acta Psychiatr. Scand. 1990; 82: 267
        • Kuo S.H.
        • Jankovic J.
        Tardive gait.
        Clin. Neurol. Neurosurg. 2008; 110: 198-201
        • Bower J.H.
        • Dickson D.W.
        • Taylor L.
        • Maraganore D.M.
        • Rocca W.A.
        Clinical correlates of the pathology underlying parkinsonism: a population perspective.
        Mov. Disord. 2002; 17: 910-916
        • Loberboym M.
        • Traves T.A.
        • Melamed E.
        • Lampl Y.
        • Hellman M.
        • Djaldetti R.
        [123 I]-EP/CIT SPECT imaging for distinguishing drug-induced Parkinsonism from Parkinson's disease.
        Mov. Disord. 2006; 21: 510-514
        • Seeman P.
        • Tinazzi M.
        Loss of dopamine neuron terminals in antipsychotic-treated schizophrenia; relation to tardive dyskinesia.
        . Jul 2013; 44: 178-183
        • Won M.S.
        • Mikos A.
        • Hurd M.
        • Fernandez H.
        • Eskin T.
        • Romrell J.
        • Okun M.S.
        Tardive parkinsonism in a bipolar patient: post-mortem examination supports a physiological rather than pathological dysfunction.
        Neurocase. 2008; 15: 66-69
        • Chung S.J.
        • Yoo H.S.
        • Moon H.
        • Oh J.S.
        • Kim J.S.
        • Park Y.H.
        • et al.
        Early-onset drug-induced parkinsonism after exposure to offenders implies nigrostriatal dopaminergic dysfunction.
        J. Neurol. Neurosurg. Psychiatry. 2017; 89: 169-174
        • Shuaib U.A.
        • Rajput A.H.
        • Robinson C.A.
        • Rajput A.
        Neuroleptic-induced Parkinsonism: clinicopathological study.
        Mov. Disord. 2016; 31: 360-365
        • Polizos P.
        • Engelhardt D.M.
        • Hoffman S.P.
        • Waizer J.
        Neurological consequences of psychotropic drug withdrawal in schizophrenic children.
        J. Autism Child. Schizophr. 1973; 3: 247-253
        • Mejia N.I.
        • Jankovic J.
        Tardive dyskinesia and withdrawal emergent syndrome in children.
        Expert. Rev. Neurother. 2010; 10: 893-901
        • Fahn S.
        The tardive dyskinesias.
        in: Matthews W.B. Glaser G.H. Recent Advances in Clinical Neurology. 4th ed. 1984 (229–260 pp.)
        • Wijemanne S.
        • Jankovic J.
        Dopa-responsive dystonia-clinical and genetic heterogeneity.
        Nat. Rev. Neurol. 2015; 11: 414-424
        • Slow E.J.
        • Lang A.E.
        Oculogyric crises: a review of phenomenology, etiology, pathogenesis, and treatment.
        Mov. Disord. 2017; 32: 193-202
        • Fitzgerald P.M.
        • Jankovic J.
        Tardive oculogyric crises.
        Neurology. 1989; 39: 1434-1437
        • Patel N.
        • Jankovic J.
        • Hallett M.
        Sensory aspects of movement disorders.
        Lancet Neurol. 2014; 13: 100-112
        • Ford B.
        • Greene P.
        • Fahn S.
        Oral and genital tardive pain syndromes.
        Neurology. 1994; 44: 2115-2119