Highlights
- •Four patients with optic neuritis and seizure were MOG antibody seropositive.
- •Episodes of seizure and optic neuritis were separated by up to ten years.
- •Seizures occurred either in the setting of ADEM or during steroid taper.
- •Seizure in a patient with prior optic neuritis should prompt MOG antibody testing.
Abstract
We describe four patients who experienced optic neuritis (ON) and seizures and were
found to have antibodies to myelin oligodendrocyte glycoprotein (MOG) in serum. The
index case was a previously healthy 39-year-old man who developed steroid dependent
ON and had a generalized seizure when steroids were tapered. He tested positive for
antibodies to MOG. We have reviewed the charts of all 11 anti-MOG antibody positive
patients in our practice and found that 4 patients, all of whom had experienced one
or more episodes of ON, also had a generalized seizure during the course of their
illness. In 2 patients – including the index case - seizure occurred during steroid
taper and in 2 others at the time of an episode of acute disseminated encephalomyelitis
(ADEM). Association of anti-MOG antibodies and relapsing demyelinating disorders of
the central nervous system is increasingly recognized. Testing for anti-MOG antibodies
should be considered in patients with optic neuritis and seizures, especially in those
with who also have a history of ADEM.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Anti-MOG antibody: the history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination.Autoimmun. Rev. 2016; 15: 307-324https://doi.org/10.1016/j.autrev.2015.12.004
- Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein.J. Neurol. Neurosurg. Psychiatry. 2015; 86: 265-272https://doi.org/10.1136/jnnp-2014-308346
- Diagnostic algorithm for relapsing acquired demyelinating syndromes in children.Neurology. 2017; 89: 269-278https://doi.org/10.1212/WNL.0000000000004117
- Anti-MOG antibodies are frequently associated with steroid-sensitive recurrent optic neuritis.Neurol. Neuroimmunol. Neuroinflammation. 2015; 2https://doi.org/10.1212/NXI.0000000000000131
- In cooperation with the N.O.S.G. (nemos), MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome.J. Neuroinflammation. 2016; 13: 280https://doi.org/10.1186/s12974-016-0718-0
- MOG antibody–positive, benign, unilateral, cerebral cortical encephalitis with epilepsy.Neurol. Neuroimmunol. Neuroinflammation. 2017; 4e322https://doi.org/10.1212/NXI.0000000000000322
- Seizures and encephalitis in myelin oligodendrocyte glycoprotein IgG disease vs aquaporin 4 IgG disease.JAMA Neurol. 2017; https://doi.org/10.1001/jamaneurol.2017.3196
- Clinical reasoning: a patient with a history of encephalomyelitis and recurrent optic neuritis.Neurology. 2017; 89: e231-e234https://doi.org/10.1212/WNL.0000000000004628
- Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in a Japanese boy with recurrent optic neuritis.Brain and Development. 2015; 37: 145-148https://doi.org/10.1016/j.braindev.2014.02.002
- Chronic relapsing inflammatory optic neuropathy (CRION).Brain. 2003; 126: 276-284https://doi.org/10.1093/brain/awg045
- Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis.Neurol. Neuroimmunol. Neuroinflammation. 2014; 1https://doi.org/10.1212/NXI.0000000000000040
- Acute disseminated encephalomyelitis followed by recurrent or monophasic optic neuritis in pediatric patients.Mult. Scler. J. 2012; 19: 941-946https://doi.org/10.1177/1352458512466317
- Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): extending the spectrum of MOG antibody positive diseases.Mult. Scler. J. 2016; 22: 1821-1829https://doi.org/10.1177/1352458516631038
Article Info
Publication History
Published online: February 03, 2018
Accepted:
January 31,
2018
Received in revised form:
January 2,
2018
Received:
November 13,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
