Immune checkpoints proteins, such as Programmed cell Death 1 (PD1), PD1 ligand (PD-L1)
and Cytotoxic T-lymphocyte Associated Protein-4 (CTLA4) are expressed by effector
immune cells, antigen-presenting cells or malignant cells and promote immunotolerance
towards tumors. Immune checkpoint inhibitors (ICI), such as the anti-PD1 monoclonal
antibody Nivolumab, enhance the immune response against malignant cells and have proven
to be efficient as first or second-line therapy for various types of malignancies.
As the use of ICI expands, specific immune-related adverse effects (irAE) involving
various organs have been reported and are considered to be caused by immune over activation.
IRAE involving the nervous system or muscle are rare and remain poorly described.
We hereby report a case of biopsy-proven myositis in a patient treated with Nivolumab
and provide a review of the literature.
Keywords
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Article Info
Publication History
Published online: February 05, 2018
Accepted:
January 24,
2018
Received in revised form:
January 9,
2018
Received:
December 10,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
