Background: Neuromyelitis optica (NMO) is a disorder distinct from multiple sclerosis, and is
characterized by the presence of anti-aquaporin4 (AQP4) antibody. Rituximab (RTX),
which is a monoclonal antibody against CD-20, is recommended as immunotherapy in guidelines,
however, the rationale is based on the results of observational or single-arm studies.
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