Background: Myelin oligodendrocyte glycoprotein (MOG) is a myelin protein expressed on the surface
of oligodendrocytes and myelin in the central nervous system. MOG is a well-known
immunogen for experimental autoimmune encephalomyelitis (EAE). EAE studies have suggested
that MOG antibody plays a direct pathogenic role in inflammatory demyelinating disease.
Recent studies have demonstrated that MOG antibody is detected in acute disseminated
encephalomyelitis (ADEM) and neuromyelitis optica spectrum disorders.
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