Background: After further studies 2016 confirmed effects of high dose biotin in chronic MS the
question arose, if biotin deficiency is frequent in MS. Low biotin levels are rare.
Biotin is synthesized by intestinal bacteria in amounts, comparable to nutritional
intake. Anangnostouli (1999) first reported lower values for biotin in CSF and serum
in MS.It could be argued, that biotin deficiency is a risk factor for MS because biotin
is an limiting coenzyme in fatty acid synthesis. In the present study we tested if
low biotin levels are more frequent in MS and therefore might prove to be a risk factor
for onset of the disease and a interesting biomarker for microbiom diversity.
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