Background: After further studies 2016 confirmed effects of high dose biotin in chronic MS the question arose, if biotin deficiency is frequent in MS. Low biotin levels are rare. Biotin is synthesized by intestinal bacteria in amounts, comparable to nutritional intake. Anangnostouli (1999) first reported lower values for biotin in CSF and serum in MS.It could be argued, that biotin deficiency is a risk factor for MS because biotin is an limiting coenzyme in fatty acid synthesis. In the present study we tested if low biotin levels are more frequent in MS and therefore might prove to be a risk factor for onset of the disease and a interesting biomarker for microbiom diversity.
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