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New developments in primary CNS lymphoma

      Lymphoma involving the nervous system has protean manifestations. We will focus on Primary CNS Lymphoma, Intra-ocular Lymphoma, Intravascular Lymphoma and Neuro-lymphomatosis. Each has characteristic features but do present difficulties in diagnosis. There have been significant advances in therapy, particularly the use of chemotherapy and concerns with the use of whole brain radiation therapy because of the risk of significant neurotoxicity in those who survive. There is controversy as to the best chemotherapy regime. As many of these patients are elderly, the toxicity of therapy is a major issue.
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