Prion disease: An overview

      Prion diseases are devastating neurodegenerative diseases in humans such as Creutzfeldt-Jakob disease (CJD) and many animal species including sheep, cows, deer and cats. CJD presents rapidly progressive dementia and other symptoms resulting in 100% death usually in months without any medicine to treat. Most CJD cases are sporadic and of unknown origin. There are also genetic forms such as familial CJD, Gerstmann-Sträussler-Scheinker syndrome and Fatal Familial Insomnia and, rarely, acquired forms including iatrogenic CJD such as due to human dura mater grafts or human pituitary derived hormones.
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