- (1)prenatal exposure to ZIKV carries a high risk of causing fetal anomalies including fetal brain disruption sequence, especially during the first and second trimesters, and that the risk may be higher among mothers with symptomatic ZIKV infections;
- (2)severe microcephaly with partially collapsed skull; thin cerebral cortices with subcortical calcifications; enlarged ventricles at birth but in 15 cases there was evolution to increase dilation and hypertensive hydrocephalus.
- (3)macular scarring and focal pigmentary retinal mottling;
- (4)congenital contractures and the occurrence of arthrogryposis
- (5)marked early hypertonia and symptoms of extrapyramidal involvement,with global neuropsychomotor development delays and incidence of epilepsy in about 30%.
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