Diffusion weighted image in neurology

      Diffusion weighted image (DWI) sequence was established by Denis LeBihan based on Brownian motion of water molecule, which was found by Einstein. Conventional MRI visualized the fixed proton atom, instead DWI visualized fixed proton sometime after Brownian motion occurred in unfixed proton. Then we can visualize water-rich area, particularly, early phase of mild ischemia, inflammation (CJD etc) and tumor. We also found neural activities induce water accumulation and found accurate activated area of the neural substrate responsible for the paradigms. We called it Diffusion fMRI (DfMRI) to visualize the accurate neuronal activities compared to Blood Oxygen Level Dependency (by S. Ogawa), that is the basis of functional MRI.
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