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Parkinson’s disease and Huntington’s disease by PET and MRI

      Parkinson's disease (PD) and Huntington’s disease (HD) are chronic neurodegenerative disease characterized clinically by disorder of movements. The underlying mechanisms of neurodegeneration in PD and HD are still unknown, and there are no disease-modifying treatments to slow the neurodegenerative processes. There is an urgent need to identify biomarkers able to monitor disease progression and assess the development and efficacy of novel disease-modifying drugs. Over the past years, neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have provided important advances in our understanding of PD and HD. PET can detect molecular changes in the brain, and it is therefore a more specific technique to assess neurotransmitter and receptor abnormalities in PD and HD brains in vivo.
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