Immune mediated neuropathy

      Immune mediated neuropathies are group of disorders including Guillain-Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy, and MAG neuropathy. Ischemic neuropathies based on ANCA-associated vasculitis may sometimes be included in this category. Because they respond well to therapeutic interventions, the knowledges to diagnose and manage immune mediated neuropathies are mandatory in general neurologists. Usually the diagnosis of immune mediated neuropathies is based on physical, electrophysiological and pathological findings. Serological confirmations of autoantibodies are sometimes important. However, since most of these disorders lack in markers for definite diagnosis, the knowledges concerning the various neuropathies which mimic immune mediated neuropathies are equally essential. In this lecture, I would like to present the tips for the appropriate differential diagnosis of immune mediated neuropathies. The importance of pathological diagnosis will be stressed. Finally, recent clinical trials to treat these disorders are also mentioned. Increased understanding of the pathophysiology of immune mediated neuropathies is expected to contribute to the development of novel therapeutic interventions.
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