Immune mediated neuropathies are group of disorders including Guillain-Barré syndrome,
chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy,
and MAG neuropathy. Ischemic neuropathies based on ANCA-associated vasculitis may
sometimes be included in this category. Because they respond well to therapeutic interventions,
the knowledges to diagnose and manage immune mediated neuropathies are mandatory in
general neurologists. Usually the diagnosis of immune mediated neuropathies is based
on physical, electrophysiological and pathological findings. Serological confirmations
of autoantibodies are sometimes important. However, since most of these disorders
lack in markers for definite diagnosis, the knowledges concerning the various neuropathies
which mimic immune mediated neuropathies are equally essential. In this lecture, I
would like to present the tips for the appropriate differential diagnosis of immune
mediated neuropathies. The importance of pathological diagnosis will be stressed.
Finally, recent clinical trials to treat these disorders are also mentioned. Increased
understanding of the pathophysiology of immune mediated neuropathies is expected to
contribute to the development of novel therapeutic interventions.
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